ArticlePflugers Archiv : European journal of physiology2014
THIK-1 (K2P13.1) is a small-conductance background K(+) channel in rat trigeminal ganglion neurons.
Article in Pflugers Archiv : European journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Frontiers in pharmacology · 2026Review
- Structure of the human KNature structural & molecular biology · 2025Article
- Gating mechanism of the two-pore-domain potassium channel THIK1.Nature structural & molecular biology · 2025Article
- Cryo-EM structure of the human THIK-1 K2P KNature structural & molecular biology · 2025Article
- The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structure of the human KbioRxiv : the preprint server for biology · 2024Article
- Research progress of two-pore potassium channel in myocardial ischemia-reperfusion injury.Frontiers in physiology · 2024Review
- Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome.Neuropharmacology · 2023Article
- Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors.PloS one · 2023Article
- Development of Non-opioid Analgesics Targeting Two-pore Domain Potassium Channels.Current neuropharmacology · 2022Review
- Two-Pore Domain Potassium Channel in Neurological Disorders.The Journal of membrane biology · 2021Review
- Higher expression of KCNK10 (TREK-2) KPflugers Archiv : European journal of physiology · 2021Article
- Verapamil Inhibits TRESK (KInternational journal of molecular sciences · 2018Article
- Adenosine AThe Journal of physiology · 2018Article
- Genes linked to species diversity in a sexually dimorphic communication signal in electric fish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Role of K₂p channels in stimulus-secretion coupling.Pflugers Archiv : European journal of physiology · 2015Review
- Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.Pflugers Archiv : European journal of physiology · 2015Review
- Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.The Journal of biological chemistry · 2014Article
- Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2.Pflugers Archiv : European journal of physiology · 2014Article
- Temperature sensitivity of two-pore (K2P) potassium channels.Current topics in membranes · 2014Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The goal of this study was to determine the molecular identity of a small-conductance (~5-pS) background K(+) channel expressed in trigeminal ganglion (TG) neurons. We tested the hypothesis that the 5-pS channel is a K2P channel by comparing the pharmacological and single-channel properties of THIK-1 expressed in HEK293 cells. As reported earlier, whole-cell THIK-1 current was inhibited by halothane and activated by arachidonic acid. Among 25 additional modulators tested, bupivacaine (100 μM), quinidine (50 μM) and Ba(2+) (3 mM) and cold (10 °C) were most effective inhibitors of THIK-1 current (>50 % inhibition). In cell-attached patches with high KCl in the pipette and bath solutions, THIK-1 produced a small-conductance (~5 pS) channel with a weak inwardly rectifying current-voltage relationship. Halothane, bupivacaine and cold inhibited the single-channel activities of both THIK-1 and the 5-pS channel in TG neurons, whereas arachidonic acid augmented them. THIK-1 expressed in HEK293 cells and the 5-pS channels in TG neurons were insensitive to hypoxia. Reverse transcriptase-PCR, Western blot and immunocytochemical analyses suggested that THIK-1 mRNA and protein were expressed in TG neurons. These results show that THIK-1 is functionally expressed in TG neurons and contributes to the background K(+) conductance.
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