ArticleIntegrative biology : quantitative biosciences from nano to macro2013
Changes in translational efficiency is a dominant regulatory mechanism in the environmental response of bacteria.
Article in Integrative biology : quantitative biosciences from nano to macro, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development.Scientific reports · 2025Article
- Are We There Yet? Assessing the Readiness of Single-Cell Proteomics to Answer Biological Hypotheses.Journal of proteome research · 2025Review
- IL-1 Receptor Contributes to the Maintenance of the Intestinal Barrier via IL-22 during Obesity and Metabolic Syndrome in Experimental Model.Microorganisms · 2024Article
- Increased Permeability of the Blood-Brain Barrier in a Diabetic Mouse Model (International journal of molecular sciences · 2024Article
- C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity.Fluids and barriers of the CNS · 2024Article
- Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis.BMC gastroenterology · 2023Article
- DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis.Cancers · 2022Article
- Origin and evolution of nonulosonic acid synthases and their relationship with bacterial pathogenicity revealed by a large-scale phylogenetic analysis.Microbial genomics · 2021Article
- Article
- From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.Annual review of microbiology · 2020Review
- The Effects of Sindbis Viral Vectors on Neuronal Function.Frontiers in cellular neuroscience · 2019Article
- Optimization of carbon and energy utilization through differential translational efficiency.Nature communications · 2018Article
- Translational control plays an important role in the adaptive heat-shock response of Streptomyces coelicolor.Nucleic acids research · 2018Article
- Article
- Chronic Physical Disturbance Substantially Alters the Response of Biological Soil Crusts to a Wetting Pulse, as Characterized by Metatranscriptomic Sequencing.Frontiers in microbiology · 2018Article
- Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells.Scientific reports · 2017Article
- Predicting Species-Resolved Macronutrient Acquisition during Succession in a Model Phototrophic Biofilm Using an Integrated 'Omics Approach.Frontiers in microbiology · 2017Article
- Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway.Science signaling · 2016Article
- Simvastatin and zinc synergistically enhance osteoblasts activity and decrease the acute response of inflammatory cells.Journal of materials science. Materials in medicine · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
To understand how cell physiological state affects mRNA translation, we used Shewanella oneidensis MR-1 grown under steady state conditions at either 20% or 8.5% O2. Using a combination of quantitative proteomics and RNA-Seq, we generated high-confidence data on >1000 mRNA and protein pairs. By using a steady state model, we found that differences in protein-mRNA ratios were primarily due to differences in the translational efficiency of specific genes. When oxygen levels were lowered, 28% of the proteins showed at least a 2-fold change in expression. Transcription levels were sp. significantly altered for 26% of the protein changes; translational efficiency was significantly altered for 46% and a combination of both was responsible for the remaining 28%. Changes in translational efficiency were significantly correlated with the codon usage pattern of the genes and measurable tRNA pools changed in response to altered O2 levels. Our results suggest that changes in the translational efficiency of proteins, in part due to altered tRNA pools, is a major determinant of regulated alterations in protein expression levels in bacteria.
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