ArticleMolecular and cellular biology2013
Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a β-catenin-dependent manner.
Article in Molecular and cellular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- BMP/WNT-Dependent Mechanisms of Junctional Epithelium Turnover.Journal of dental research · 2026Article
- Roles of Wnt signaling pathway in cementum formation, cementum regeneration, and cementocyte function.Journal of Zhejiang University. Science. B · 2026Review
- BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications.Frontiers in cell and developmental biology · 2023Review
- Stage-Specific Role ofInternational journal of molecular sciences · 2021Article
- Cell dynamics in Hertwig's epithelial root sheath are regulated by β-catenin activity during tooth root development.Journal of cellular physiology · 2021Article
- USP34 regulates tooth root morphogenesis by stabilizing NFIC.International journal of oral science · 2021Article
- Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development.Development (Cambridge, England) · 2021Article
- Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh.Frontiers in cell and developmental biology · 2021Review
- Article
- Expression dynamics of integrin α2, α3, and αV upon osteogenic differentiation of human mesenchymal stem cells.Stem cell research & therapy · 2020Article
- Article
- Amelogenic transcriptome profiling in ameloblast-like cells derived from adult gingival epithelial cells.Scientific reports · 2019Article
- Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.Journal of molecular histology · 2019Article
- Phenotypic Analyses of Genetically Modified Mice for BMP Receptors.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Generation and Identification of Genetically Modified Mice for BMP Receptors.Methods in molecular biology (Clifton, N.J.) · 2019Article
- [The role of bone morphogenetic protein signaling pathway in tooth root development].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018Review
- Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization.Journal of molecular histology · 2018Article
- Loss of Stemness, EMT, and Supernumerary Tooth Formation in CebpbScientific reports · 2018Article
- TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition.Cold Spring Harbor perspectives in biology · 2018Review
- Cellular and molecular mechanisms of tooth root development.Development (Cambridge, England) · 2017Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The differentiation of dental epithelia into enamel-producing ameloblasts or the root epithelial lineage compartmentalizes teeth into crowns and roots. Bmp signaling has been linked to enamel formation, but its role in root epithelial lineage differentiation is unclear. Here we show that cessation of epithelial Bmp signaling by Bmpr1a depletion during the differentiation stage switched differentiation of crown epithelia into the root lineage and led to formation of ectopic cementum-like structures. This phenotype is related to the upregulation of Wnt/β-catenin signaling and epithelial-mesenchymal transition (EMT). Although epithelial β-catenin depletion during the differentiation stage also led to variable enamel defect and precocious/ectopic formation of fragmented root epithelia in some teeth, it did not cause ectopic cementogenesis and inhibited EMT in cultured dental epithelia. Concomitant epithelial β-catenin depletion rescued EMT and ectopic cementogenesis caused by Bmpr1a depletion. These data suggested that Bmp and Wnt/β-catenin pathways interact antagonistically in dental epithelia to regulate the root lineage differentiation and EMT. These findings will aid in the design of new strategies to promote functional differentiation in the regeneration and tissue engineering of teeth and will provide new insights into the dynamic interactions between the Bmp and Wnt/β-catenin pathways during cell fate decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.