ArticleHuman heredity2013
The positive association of obesity variants with adulthood adiposity strengthens over an 80-year period: a gene-by-birth year interaction.
Article in Human heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Genetic risk for high body mass index before and amidst the obesity epidemic: Cross-cohort analysis of four british birth cohort studies.PLoS genetics · 2026Article
- Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations.Circulation. Genomic and precision medicine · 2023Article
- Modeling Interaction and Dispersion Effects in the Analysis of Gene-by-Environment Interaction.Behavior genetics · 2022Article
- Genetic risk of obesity as a modifier of associations between neighbourhood environment and body mass index: an observational study of 335 046 UK Biobank participants.BMJ nutrition, prevention & health · 2020Article
- Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts.PloS one · 2020Article
- Quantifying the impact of genes on body mass index during the obesity epidemic: longitudinal findings from the HUNT Study.BMJ (Clinical research ed.) · 2019Article
- Education can reduce health differences related to genetic risk of obesity.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States.Demography · 2018Article
- Trends in the distribution of body mass index and waist circumference among South Korean adults, 1998-2014.European journal of clinical nutrition · 2018Article
- Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution.American journal of human genetics · 2017Article
- Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.Physiological reviews · 2017Review
- Mortality selection in a genetic sample and implications for association studies.International journal of epidemiology · 2017Article
- Translating Polygenic Analysis for Prevention: From Who to How.Circulation. Cardiovascular genetics · 2017Article
- Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice.International journal of molecular sciences · 2016Article
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
- Established BMI-associated genetic variants and their prospective associations with BMI and other cardiometabolic traits: the GLACIER Study.International journal of obesity (2005) · 2016Article
- Opportunities and challenges of big data for the social sciences: The case of genomic data.Social science research · 2016Article
- Pediatric obesity. An introduction.Appetite · 2015Article
- Lifetime Socioeconomic Status, Historical Context, and Genetic Inheritance in Shaping Body Mass in Middle and Late Adulthood.American sociological review · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveTo test the hypothesis that the statistical effect of obesity-related genetic variants on adulthood adiposity traits depends on birth year.
methodsThe study sample included 907 related, non-Hispanic White participants in the Fels Longitudinal Study, born between 1901 and 1986, and aged 25-64.99 years (474 females; 433 males) at the time of measurement. All had both genotype data from which a genetic risk score (GRS) composed of 32 well-replicated obesity-related common single nucleotide polymorphisms was created, and phenotype data [including body mass index (BMI), waist circumference, and the sum of four subcutaneous skinfolds]. Maximum likelihood-based variance components analysis was used to estimate trait heritabilities, main effects of GRS and birth year, GRS-by-birth year interaction, sex, and age.
resultsPositive GRS-by-birth year interaction effects were found for BMI (p < 0.001), waist circumference (p = 0.007), and skinfold thickness (p < 0.007). For example, each one-allele increase in GRS was estimated to result in a 0.16 increase in BMI among males born in 1930 compared to a 0.47 increase among those born in 1970.
conclusionsThese novel findings suggest the influence of common obesity susceptibility variants has increased during the obesity epidemic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.