Trial reportHuman heredity2013
Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial.
Trial report in Human heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- Trial
- Genetic modifiers of cardiorespiratory fitness response to lifestyle intervention.Medicine and science in sports and exercise · 2014Trial
- Review
- Strategies to Understand the Weight-Reduced State: Genetics and Brain Imaging.Obesity (Silver Spring, Md.) · 2021Review
- Benefits and limitations of genome-wide association studies.Nature reviews. Genetics · 2019Review
- Genetic predictors of weight loss in overweight and obese subjects.Scientific reports · 2019Article
- Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism.Nature communications · 2019Article
- Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain.Obesity (Silver Spring, Md.) · 2018Article
- The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures Project: Rationale and Approach.Obesity (Silver Spring, Md.) · 2018Article
- Insight into rheumatological cause and effect through the use of Mendelian randomization.Nature reviews. Rheumatology · 2016Review
- NIH working group report-using genomic information to guide weight management: From universal to precision treatment.Obesity (Silver Spring, Md.) · 2016Review
- USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis.Genetic epidemiology · 2016Article
- Look inside Look AHEAD: why the glass is more than half-full.Current diabetes reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimsThe present study identified genetic predictors of weight change during behavioral weight loss treatment.
methodsParticipants were 3,899 overweight/obese individuals with type 2 diabetes from Look AHEAD, a randomized controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabetes support and education, on cardiovascular outcomes. Analyses focused on associations of single nucleotide polymorphisms (SNPs) on the Illumina CARe iSelect (IBC) chip (minor allele frequency >5%; n = 31,959) with weight change at year 1 and year 4, and weight regain at year 4, among individuals who lost ≥ 3% at year 1.
resultsTwo novel regions of significant chip-wide association with year-1 weight loss in ILI were identified (p < 2.96E-06). ABCB11 rs484066 was associated with 1.16 kg higher weight per minor allele at year 1, whereas TNFRSF11A, or RANK, rs17069904 was associated with 1.70 kg lower weight per allele at year 1.
conclusionsThis study, the largest to date on genetic predictors of weight loss and regain, indicates that SNPs within ABCB11, related to bile salt transfer, and TNFRSF11A, implicated in adipose tissue physiology, predict the magnitude of weight loss during behavioral intervention. These results provide new insights into potential biological mechanisms and may ultimately inform weight loss treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.