ArticleHuman heredity2013
Identification of pleiotropic genetic effects on obesity and brain anatomy.
Article in Human heredity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Exploring the molecular basis of the genetic correlation between body mass index and brain morphological traits.PLoS genetics · 2025Article
- Independent effects of posttraumatic stress disorder diagnosis and metabolic syndrome status on prefrontal cortical thickness and subcortical gray matter volumes.Dialogues in clinical neuroscience · 2023Article
- Identification of four novel loci associated with psychotropic drug-induced weight gain in a Swiss psychiatric longitudinal study: A GWAS analysis.Molecular psychiatry · 2023Article
- Why do humans undergo an adiposity rebound? Exploring links with the energetic costs of brain development in childhood using MRI-based 4D measures of total cerebral blood flow.International journal of obesity (2005) · 2022Article
- Metabolic syndrome predictors of brain gray matter volume in an age-stratified community sample of 776 Mexican- American adults: Results from the genetics of brain structure image archive.Frontiers in aging neuroscience · 2022Article
- Association of HIV-1 Infection and Antiretroviral Therapy With Type 2 Diabetes in the Hispanic Population of the Rio Grande Valley, Texas, USA.Frontiers in medicine · 2021Article
- Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study.JAMA psychiatry · 2020Article
- Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The development of executive function in early childhood is inversely related to change in body mass index: Evidence for an energetic tradeoff?Developmental science · 2020Article
- Impact of Psychotropic Medication Effects on Obesity and the Metabolic Syndrome in People With Serious Mental Illness.Frontiers in endocrinology · 2020Review
- Shared genetic influences on adolescent body mass index and brain structure: A voxel-based morphometry study in twins.NeuroImage · 2019Article
- A hypothesis linking the energy demand of the brain to obesity risk.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Elevated Body Mass Index is Associated with Increased Integration and Reduced Cohesion of Sensory-Driven and Internally Guided Resting-State Functional Brain Networks.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Additive genetic variation in the craniofacial skeleton of baboons (genus Papio) and its relationship to body and cranial size.American journal of physical anthropology · 2018Article
- Contributions of polygenic risk for obesity to PTSD-related metabolic syndrome and cortical thickness.Brain, behavior, and immunity · 2017Article
- An Analytic Solution to the Computation of Power and Sample Size for Genetic Association Studies under a Pleiotropic Mode of Inheritance.Human heredity · 2016Article
- Multi-level block permutation.NeuroImage · 2015Article
- Genome-wide significant linkage of schizophrenia-related neuroanatomical trait to 12q24.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- Depression, obesity, and metabolic syndrome: prevalence and risks of comorbidity in a population-based representative sample of Mexican Americans.The Journal of clinical psychiatry · 2015Article
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16 authors.
Funding
Abstract
BACKGROUND/
aimsObesity is a major contributor to the global burden of chronic disease and disability, though current knowledge of causal biologic underpinnings is lacking. Through the regulation of energy homeostasis and interactions with adiposity and gut signals, the brain is thought to play a significant role in the development of this disorder. While neuroanatomical variation has been associated with obesity, it is unclear if this relationship is influenced by common genetic mechanisms. In this study, we sought genetic components that influence both brain anatomy and body mass index (BMI) to provide further insight into the role of the brain in energy homeostasis and obesity.
methodsMRI images of brain anatomy were acquired in 839 Mexican American individuals from large extended pedigrees. Bivariate linkage and quantitative analyses were performed in SOLAR.
resultsGenetic factors associated with an increased BMI were also associated with a reduced cortical surface area and subcortical volume. We identified two genome-wide quantitative trait loci that influenced BMI and the ventral diencephalon volume, and BMI and the supramarginal gyrus surface area, respectively.
conclusionsThis study represents the first genetic analysis seeking evidence of pleiotropic effects acting on both brain anatomy and BMI. Our results suggest that a region on chromosome 17 contributes to the development of obesity, potentially through leptin-induced signaling in the hypothalamus, and that a region on chromosome 3 appears to jointly influence the food-related reward circuitry and the supramarginal gyrus.
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