ArticleThe Journal of physiology2013
Modelling genetic reorganization in the mouse spinal cord affecting left-right coordination during locomotion.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- The Bcm rule allows a spinal cord model to learn rhythmic movements.Biological cybernetics · 2023Article
- The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice.eLife · 2022Article
- Computational Modeling of Spinal Locomotor Circuitry in the Age of Molecular Genetics.International journal of molecular sciences · 2021Review
- Relative Contribution of Proprioceptive and Vestibular Sensory Systems to Locomotion: Opportunities for Discovery in the Age of Molecular Science.International journal of molecular sciences · 2021Review
- Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling.Frontiers in neural circuits · 2020Article
- On the Organization of the Locomotor CPG: Insights From Split-Belt Locomotion and Mathematical Modeling.Frontiers in neuroscience · 2020Article
- Locomotor-related V3 interneurons initiate and coordinate muscles spasms after spinal cord injury.Journal of neurophysiology · 2019Article
- Spinal V3 Interneurons and Left-Right Coordination in Mammalian Locomotion.Frontiers in cellular neuroscience · 2019Article
- State-dependent rhythmogenesis and frequency control in a half-center locomotor CPG.Journal of neurophysiology · 2018Article
- Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds.eLife · 2017Article
- Morphology and the gradient of a symmetric potential predict gait transitions of dogs.Biological cybernetics · 2017Article
- Development and Training of a Neural Controller for Hind Leg Walking in a Dog Robot.Frontiers in neurorobotics · 2017Article
- Organization of flexor-extensor interactions in the mammalian spinal cord: insights from computational modelling.The Journal of physiology · 2016Article
- Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM.Journal of neurophysiology · 2016Article
- Review
- Peeling back the layers of locomotor control in the spinal cord.Current opinion in neurobiology · 2015Review
- Organization of left-right coordination of neuronal activity in the mammalian spinal cord: Insights from computational modelling.The Journal of physiology · 2015Article
- Mechanisms of left-right coordination in mammalian locomotor pattern generation circuits: a mathematical modeling view.PLoS computational biology · 2015Article
- Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The spinal neural circuit contains inhibitory (CINi) and excitatory (CINe) commissural interneurons with axons crossing the mid-line. Direction of these axons to the other side of the cord is controlled by axon guidance molecules, such as Netrin-1 and DCC. The cord also contains glutamatergic interneurons, whose axon guidance involves the EphA4 receptor. In EphA4 knockout (KO) and Netrin-1 KO mice, the normal left-right alternating pattern is replaced with a synchronized hopping gait, and the cord of DCC KO mice exhibits uncoordinated left and right oscillations. To investigate the effects of these genetic transformations, we used a computational model of the spinal circuits containing left and right rhythm-generating neuron populations (RGs), each with a subpopulation of EphA4-positive neurons, and CINi and CINe populations mediating mutual inhibition and excitation between the left and right RGs. In the EphA4 KO circuits, half of the EphA4-positive axons crossed the mid-line and excited the contralateral RG neurons. In the Netrin-1 KO model, the number of contralateral CINi projections was significantly reduced, while in the DCC KO model, the numbers of both CINi and CINe connections were reduced. In our simulations, the EphA4 and Netrin-1 KO circuits switched from the left-right alternating pattern to a synchronized hopping pattern, and the DCC KO network exhibited uncoordinated left-right activity. The amplification of inhibitory interactions re-established an alternating pattern in the EphA4 and DCC KO circuits, but not in the Netrin-1 KO network. The model reproduces the genetic transformations and provides insights into the organization of the spinal locomotor network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.