ReviewNeuroendocrinology2013
Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders.
Review in Neuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Association of metabolic syndrome and its components with the risk of depressive symptoms: A systematic review and meta-analysis of cohort studies.Journal of affective disorders · 2023Pooled it
- Pilot evaluation of an educational and lived experience training program on ketogenic metabolic therapy in mental health care for health care professionals.Frontiers in psychiatry · 2026Trial
- Metabolic syndrome in youth with bipolar spectrum disorders treated with second-generation antipsychotics: baseline results from the community-based pragmatic MOBILITY Trial.European child & adolescent psychiatry · 2025Trial
- Associations of childhood maltreatment types and timing with oxidative stress in formerly out-of-home placed young adults.European journal of psychotraumatology · 2026Article
- Longitudinal and Bidirectional Relationships Between Sleep, Emotional Wellbeing and Weight Status in Childhood and Adolescence: Growing Up in Scotland Cohort Analysis.Journal of sleep research · 2026Article
- Reno-Metabolic Multimorbidity and Psychiatric Comorbidity: Development of a Renal-Psychiatric/Psychosomatic Burden Score in a Real-World Cohort.Medicina (Kaunas, Lithuania) · 2025Article
- Gender Differences in Prevalence and Clinical Correlates of Initial-Treatment and Drug-Naïve Bipolar Disorder Patients With Metabolic Syndrome: A Cross-Sectional Study.Alpha psychiatry · 2025Article
- GLP-1 Receptor Agonists in Mood Disorders: A Psychiatric Perspective.Life (Basel, Switzerland) · 2025Review
- The endocannabinoidome-gut microbiome-brain axis as a novel therapeutic target for autism spectrum disorder.Journal of biomedical science · 2025Review
- Serum proteomic correlates of mental health symptoms in a representative UK population sample.Brain, behavior, & immunity - health · 2025Article
- Early life adversity and the comorbidity of psychopathology and cardiometabolic disorders: insights from the UK Biobank.BMJ public health · 2025Article
- Striatal dopamine gene network moderates the effect of early adversity on the risk for adult psychiatric and cardiometabolic comorbidity.Scientific reports · 2024Article
- Association between olfactory function and metabolic syndrome in bipolar disorder patients: a cross-sectional study.BMC psychiatry · 2024Article
- Better understanding of c-reactive protein and leukocytes in psychiatric inpatients with affective disorders: A biopsychosocial approach.World journal of clinical cases · 2024Article
- Investigating the association between metabolic syndrome conditions and perinatal mental illness: a national administrative claims study.BMC pregnancy and childbirth · 2024Observational
- Article
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Article
- Editorial: Molecular links between metabolism and neural dysfunction.Frontiers in neuroscience · 2023Article
- Prevalence of the metabolic syndrome and associated factors among inpatients with severe mental illness in Botswana: a cross-sectional study.BMC cardiovascular disorders · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The increased prevalence and high comorbidity of metabolic syndrome (MetS) and mental health disorders (MHDs) have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between MetS and MHDs including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems (including the serotonergic, dopaminergic, and neuropeptide Y systems) as well as dysregulation of the hypothalamic-pituitary-adrenal axis. MetS in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to MetS and psychopathologies. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions that can interrupt the transfer of increased risk of the disorders to the next generation need to be developed. © 2013 S. Karger AG, Basel.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.