ArticleJournal of the American Heart Association2013
Hostility, health behaviors, and risk of recurrent events in patients with stable coronary heart disease: findings from the Heart and Soul Study.
Article in Journal of the American Heart Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02310932 (Improving Mental Health Through Integration With Primary Care in Rural Karnataka), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Mental Health Through Integration With Primary Care in Rural Karnataka
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Anger, hostility and risk of stroke: a meta-analysis of cohort studies.Journal of neurology · 2019Pooled it
- The Effect of Hostility Reduction on Autonomic Control of the Heart and Vasculature: A Randomized Controlled Trial.Psychosomatic medicine · 2016Trial
- Anger, Cynical Distrust, Nightmare Distress and Insomnia Among Nursing Personnel.Journal of clinical medicine · 2026Article
- Multidimensional sleep health and resting blood pressure in young adults: the role of negative affect.Journal of behavioral medicine · 2026Article
- Physical Aggression and Coronary Artery Calcification: A North Texas Healthy Heart Study.International journal of behavioral medicine · 2022Article
- The associations of hostility and defensiveness with telomere length are influenced by sex and health status.Biology of sex differences · 2021Article
- Community-level socioeconomic inequality in the incidence of ischemic heart disease: a nationwide cohort study.BMC cardiovascular disorders · 2020Article
- Factors associated with hostility among people living with HIV/AIDS in Northeast China: a cross-sectional study.BMC public health · 2019Article
- Role of personality in cardiovascular diseases: An issue that needs to be focused too!Indian heart journal · 2018Review
- Flow mediated vasodilation compared with carotid intima media thickness in the evaluation of early cardiovascular damage in menopausal women and the influence of biological and psychosocial factors.BMC women's health · 2018Article
- Anger and Coronary Artery Disease in Women Submitted to Coronary Angiography: A 48-Month Follow-Up.Arquivos brasileiros de cardiologia · 2018Article
- Job-related burnout is associated with brain neurotransmitter levels in Chinese medical workers: a cross-sectional study.The Journal of international medical research · 2018Article
- Anger, hostility, and hospitalizations in patients with heart failure.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- High levels of cynical distrust partly predict premature mortality in middle-aged to ageing men.Journal of behavioral medicine · 2017Article
- The Association of Cigarette Smoking With High-Frequency Heart Rate Variability: An Ecological Momentary Assessment Study.Psychosomatic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHostility is a significant predictor of mortality and cardiovascular events in patients with coronary heart disease (CHD), but the mechanisms that explain this association are not well understood. The purpose of this study was to evaluate potential mechanisms of association between hostility and adverse cardiovascular outcomes. METHODS AND
resultsWe prospectively examined the association between self-reported hostility and secondary events (myocardial infarction, heart failure, stroke, transient ischemic attack, and death) in 1022 outpatients with stable CHD from the Heart and Soul Study. Baseline hostility was assessed using the 8-item Cynical Distrust scale. Cox proportional hazard models were used to determine the extent to which candidate biological and behavioral mediators changed the strength of association between hostility and secondary events. During an average follow-up time of 7.4 ± 2.7 years, the age-adjusted annual rate of secondary events was 9.5% among subjects in the highest quartile of hostility and 5.7% among subjects in the lowest quartile (age-adjusted hazard ratio [HR]: 1.68, 95% confidence interval [CI]: 1.30 to 2.17; P < 0.0001). After adjustment for cardiovascular risk factors, participants with hostility scores in the highest quartile had a 58% greater risk of secondary events than those in the lowest quartile (HR: 1.58, 95% CI: 1.19 to 2.09; P = 0.001). This association was mildly attenuated after adjustment for C-reactive protein (HR: 1.41, 95% CI, 1.06 to 1.87; P = 0.02) and no longer significant after further adjustment for smoking and physical inactivity (HR: 1.25, 95% CI: 0.94 to 1.67; P = 0.13).
conclusionsHostility was a significant predictor of secondary events in this sample of outpatients with baseline stable CHD. Much of this association was moderated by poor health behaviors, specifically physical inactivity and smoking.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.