ArticleSchizophrenia bulletin2014
Elevated antisaccade error rate as an intermediate phenotype for psychosis across diagnostic categories.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Cognitive control in schizophrenia spectrum disorders is associated with long-term movement activity rather than single-bout exercise.European archives of psychiatry and clinical neuroscience · 2026Article
- Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes.Translational psychiatry · 2025Article
- Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations.Molecular psychiatry · 2025Article
- Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations.medRxiv : the preprint server for health sciences · 2024Article
- Oculomotor Abnormalities and Aberrant Neuro-Developmental Markers: Composite Endophenotype for Bipolar I Disorder: Anomalies Oculomotrices et Marqueurs Neuro-Développementaux Aberrants : Endophénotype Composite du Trouble Bipolaire I.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes.Advances in neurobiology · 2024Review
- Clinical characterization and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT)-1.Schizophrenia research · 2023Article
- Emotional scene processing in biotypes of psychosis.Psychiatry research · 2023Article
- The deficient cue monitoring and the facilitating effect of prosocial intention on prospective memory in patients with schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2023Article
- A machine learning approach on whole blood immunomarkers to identify an inflammation-associated psychosis onset subgroup.Molecular psychiatry · 2023Article
- Clinical Saccadometry: Establishing Evaluative Standards Using a Simplified Video Oculography Protocol in the Adult Population.Journal of the American Academy of Audiology · 2023Article
- A tablet-based quantitative assessment of manual dexterity for detection of early psychosis.Frontiers in psychiatry · 2023Article
- Antisaccade error rates and gap effects in psychosis syndromes from bipolar-schizophrenia network for intermediate phenotypes 2 (B-SNIP2).Psychological medicine · 2022Article
- Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.Schizophrenia bulletin · 2022Article
- Sex-Specific Changes in Choroid Vasculature Among Patients with Schizophrenia and Bipolar Disorder.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Reduced white matter microstructure in bipolar disorder with and without psychosis.Bipolar disorders · 2021Article
- Deficits in generalized cognitive ability, visual sensorimotor function, and inhibitory control represent discrete domains of neurobehavioral deficit in psychotic disorders.Schizophrenia research · 2021Article
- Altered Effective Connectivity within an Oculomotor Control Network in Unaffected Relatives of Individuals with Schizophrenia.Brain sciences · 2021Article
- Biomarker Profiles in Psychosis Risk Groups Within Unaffected Relatives Based on Familiality and Age.Schizophrenia bulletin · 2021Article
- Eye movements in patients in early psychosis with and without a history of cannabis use.NPJ schizophrenia · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundElevated antisaccade error rate, reflecting problems with inhibitory behavioral control, is a promising intermediate phenotype for schizophrenia. Here, we consider whether it marks liability across psychotic disorders via common or different neurophysiological mechanisms and whether it represents a neurocognitive risk indicator apart from the generalized cognitive deficit.
methodsSchizophrenia (n = 267), schizoaffective (n = 150), and psychotic bipolar (n = 202) probands, their first-degree relatives (ns = 304, 193, 242, respectively), and healthy controls (n = 244), participating in the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium, performed antisaccade and prosaccade tasks and completed a neuropsychological battery.
resultsAntisaccade error rate was elevated in proband groups with greatest deficit observed in schizophrenia and was unrelated to symptoms and antipsychotic treatment. Increased error rate was also observed among relatives, even those without history of psychosis or psychosis spectrum personality traits. Relatives' deficits were similar across proband diagnoses. Error rate was familial and remained elevated in proband and relative groups after accounting for generalized cognitive impairment. Speed of attentional shifting, indexed by prosaccade latency, was similarly influenced in all groups by manipulations that freed vs increasingly engaged attention systems and was inversely associated with antisaccade error rate in all but schizophrenia probands.
conclusionsThese findings indicate that elevated antisaccade error rate represents an intermediate phenotype for psychosis across diagnostic categories, and that it tracks risk beyond that attributable to the generalized cognitive deficit. The greater severity of antisaccade impairment in schizophrenia and its independence from attention shifting processes suggest more severe and specific prefrontal inhibitory control deficits in this disorder.
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