Evidence map›Paper›PMID 24080654›Full record

ArticleAntimicrobial agents and chemotherapy2013

Antibiotic-induced autoactivation of IS256 in Staphylococcus aureus.

Franziska Schreiber, Christiane Szekat, Michaele Josten, Hans-Georg Sahl, Gabriele Bierbaum

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. New perspectives on mobile genetic elements: a paradigm shift for managing the antibiotic resistance crisis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  7. Review
  8. Article
  9. A Novel Family ofFrontiers in microbiology · 2020
    Article
  10. Article
  11. Influence of ISAntimicrobial agents and chemotherapy · 2017
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Franziska SchreiberInstitute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany.
Christiane Szekat
Michaele Josten
Hans-Georg Sahl
Gabriele Bierbaum

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 3' end of rsbU, encoding the positive regulator of the stress factor sigma B, was identified as a hot spot for spontaneous IS256 insertion in Staphylococcus aureus SA137/93G. Interestingly, subinhibitory concentrations of chloramphenicol in combination with heat stress, as well as linezolid and spectinomycin at physiological temperatures, selected for such rsbU::IS256 insertion mutants. In consequence of the inactivation of rsbU, the IS256 transposition frequency was increased 4-fold in S. aureus HG001.

Indexed as

AcetamidesAnti-Bacterial AgentsChloramphenicolDNA Transposable ElementsGene Expression Regulation, BacterialLinezolidMutationOxazolidinonesSpectinomycinStaphylococcus aureusTemperatureAcetamidesAnti-Bacterial AgentsChloramphenicolDNA Transposable ElementsLinezolidOxazolidinonesSpectinomycin

Identifiers

PMID24080654
PMCPMC3837861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.