ArticlePsychiatry research2013
APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease.
Article in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 76 citations in OpenAlex.
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- Hyperintensity of the left piriform cortex and amygdala on T2-weighted FLAIR images in patients with probable Alzheimer's disease correlates with cerebral cortical atrophy.Acta radiologica open · 2025Article
- Neuroanatomical changes in early Parkinson's disease with mild cognitive impairment: gray matter and white matter damage.Frontiers in neurology · 2025Article
- Associations and interactions betweenBrain communications · 2025Article
- APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI.Scientific reports · 2024Article
- Clinically feasible automated MRI volumetry of the brain as a prognostic marker in subjective and mild cognitive impairment.Frontiers in neurology · 2024Article
- Alterations in large-scale resting-state network nodes following transcranial focused ultrasound of deep brain structures.Frontiers in human neuroscience · 2024Article
- Age differences in cortical thickness and their association with cognition in chimpanzee (Pan troglodytes).Neurobiology of aging · 2023Article
- Testing central auditory processing abilities in older adults with and without dementia using the consonant-vowel dichotic listening task.Frontiers in dementia · 2023Article
- FDG-PET-based neural correlates of Addenbrooke's cognitive examination III scores in Alzheimer's disease and frontotemporal degeneration.Frontiers in psychology · 2023Article
- The key role of depression and supramarginal gyrus in frailty: a cross-sectional study.Frontiers in aging neuroscience · 2023Article
- Time- and dose-dependent volume decreases in subcortical grey matter structures of glioma patients after radio(chemo)therapy.Clinical and translational radiation oncology · 2022Article
- The relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer's disease: an exploratory analysis.Alzheimer's research & therapy · 2022Article
- Right entorhinal cortical thickness is associated with Mini-Mental State Examination scores from multi-country datasets using MRI.Neuroradiology · 2022Article
- Concordance of Alzheimer's Disease Subtypes Produced from Different Representative Morphological Measures: A Comparative Study.Brain sciences · 2022Article
- A Graph Gaussian Embedding Method for Predicting Alzheimer's Disease Progression With MEG Brain Networks.IEEE transactions on bio-medical engineering · 2021Article
- Relation of retinal and hippocampal thickness in patients with amnestic mild cognitive impairment and healthy controls.Brain and behavior · 2021Article
- The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer's Disease Pathology.Life (Basel, Switzerland) · 2021Review
- Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.Nature communications · 2021Observational
- Electrophysiological Biomarkers of Epileptogenicity in Alzheimer's Disease.Frontiers in human neuroscience · 2021Review
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
Across species structural and functional hemispheric asymmetry is a fundamental feature of the brain. Environmental and genetic factors determine this asymmetry during brain development and modulate its interaction with brain disorders. The e4 allele of the apolipoprotein E gene (APOE-4) is a risk factor for Alzheimer's disease, associated with regionally specific effects on brain morphology and function during the life span. Furthermore, entorhinal and hippocampal hemispheric asymmetry could be modified by pathology during Alzheimer's disease development. Using high-resolution magnetic resonance imaging and a cortical unfolding technique we investigated whether carrying the APOE-4 allele influences hemispheric asymmetry in the entorhinal cortex and the hippocampus among patients with Alzheimer's disease as well as in middle-aged and older cognitively healthy individuals. APOE-4 carriers showed a thinner entorhinal cortex in the left hemisphere when compared with the right hemisphere across all participants. Non-carriers of the allele showed this asymmetry only in the patient group. Cortical thickness in the hippocampus did not vary between hemispheres among APOE-4 allele carriers and non-carriers. The APOE-4 allele modulates hemispheric asymmetry in entorhinal cortical thickness. Among Alzheimer's disease patients, this asymmetry might be less dependent on the APOE genotype and a more general marker of incipient disease pathology.
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