Trial reportPsychiatry research2013
Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study.
Trial report in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Differentiation between bipolar disorder and major depressive disorder in adolescents: from clinical to biological biomarkers.Frontiers in human neuroscience · 2023Pooled it
- Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.Brain imaging and behavior · 2021Pooled it
- Differentiating bipolar disorder from unipolar depression in youth: A systematic literature review of neuroimaging research studies.Psychiatry research. Neuroimaging · 2021Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Meta-analysis of Functional Neuroimaging of Major Depressive Disorder in Youth.JAMA psychiatry · 2015Pooled it
- Cortisol effects on brain functional connectivity during emotion processing in women with depression.Journal of affective disorders · 2021Trial
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- Understanding Pediatric Bipolar Disorder Through the Investigation of Clinical, Neuroanatomic, Neurophysiological and Neurocognitive Dimensions: A Pilot Study.Brain sciences · 2025Article
- Causal effects of diabetic retinopathy on depression, anxiety and bipolar disorder in the European population: a Mendelian randomization study.Journal of endocrinological investigation · 2024Article
- Different MRI structural processing methods do not impact functional connectivity computation.Scientific reports · 2023Article
- Characterizing Unipolar and Bipolar Depression by Alterations in Inflammatory Mediators and the Prefrontal-Limbic Structural Network.Depression and anxiety · 2023Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- Article
- Identifying Psychological Symptoms Based on Facial Movements.Frontiers in psychiatry · 2020Article
- QEEG in affective disorder: about to be a biomarker, endophenotype and predictor of treatment response.Heliyon · 2018Review
- Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.Brain imaging and behavior · 2018Article
- Differential Abnormal Pattern of Anterior Cingulate Gyrus Activation in Unipolar and Bipolar Depression: an fMRI and Pattern Classification Approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Positive Emotion Specificity and Mood Symptoms in an Adolescent Outpatient Sample.Cognitive therapy and research · 2017Article
- Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity.Orphanet journal of rare diseases · 2017Article
- Distinguishing Bipolar Depression from Unipolar Depression in Youth: Preliminary Findings.Journal of child and adolescent psychopharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Failure to distinguish bipolar depression (BDd) from the unipolar depression of major depressive disorder (UDd) in adolescents has significant clinical consequences. We aimed to identify differential patterns of functional neural activity in BDd versus UDd and employed two (fearful and happy) facial expression/ gender labeling functional magnetic resonance imaging (fMRI) experiments to study emotion processing in 10 BDd (8 females, mean age=15.1 ± 1.1) compared to age- and gender-matched 10 UDd and 10 healthy control (HC) adolescents who were age- and gender-matched to the BDd group. BDd adolescents, relative to UDd, showed significantly lower activity to both intense happy (e.g., insula and temporal cortex) and intense fearful faces (e.g., frontal precentral cortex). Although the neural regions recruited in each group were not the same, both BDd and UDd adolescents, relative to HC, showed significantly lower neural activity to intense happy and mild happy faces, but elevated neural activity to mild fearful faces. Our results indicated that patterns of neural activity to intense positive and negative emotional stimuli can help differentiate BDd from UDd in adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.