ArticlePsychoneuroendocrinology2013
Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women.
Article in Psychoneuroendocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.Molecular psychiatry · 2018Pooled it
- Meta-analysis of genome-wide association studies of anxiety disorders.Molecular psychiatry · 2016Pooled it
- Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans.Journal of affective disorders · 2015Pooled it
- A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction.PloS one · 2018Trial
- Longitudinal Analysis of Peripheral MicroRNA Expression and Depressive Symptom Severity Change in a Community Cohort.Epigenomes · 2026Article
- The relationship between social adversity, micro-RNA expression and post-traumatic stress in a prospective, community-based cohort.Nature. Mental health · 2026Article
- Regional autozygosity association with albumin-to-creatinine ratio reveals a novel FTO region in an Indigenous Australian population.European journal of human genetics : EJHG · 2025Article
- Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers.Biology · 2023Review
- Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy.The American journal of psychiatry · 2022Article
- Immune system regulation and role of the human leukocyte antigen in posttraumatic stress disorder.Neurobiology of stress · 2021Review
- Posttraumatic stress disorder: from gene discovery to disease biology.Psychological medicine · 2021Review
- On the functional relevance of spatiotemporally-specific patterns of experience-dependent long noncoding RNA expression in the brain.RNA biology · 2021Review
- Genomic factors underlying sex differences in trauma-related disorders.Neurobiology of stress · 2021Article
- Gender- and Sex-Based Contributors to Sex Differences in PTSD.Current psychiatry reports · 2020Review
- LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer.Molecular cancer · 2019Article
- A review of epigenetic contributions to post-traumatic stress disorder .Dialogues in clinical neuroscience · 2019Review
- Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.JAMA psychiatry · 2019Article
- Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster.Brain sciences · 2019Article
- Polygenic risk associated with post-traumatic stress disorder onset and severity.Translational psychiatry · 2019Article
- DNA methylation correlates of PTSD: Recent findings and technical challenges.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is a common and debilitating mental disorder with a particularly high burden for women. Emerging evidence suggests PTSD may be more heritable among women and evidence from animal models and human correlational studies suggest connections between sex-linked biology and PTSD vulnerability, which may extend to the disorder's genetic architecture. We conducted a genome-wide association study (GWAS) of PTSD in a primarily African American sample of women from the Detroit Neighborhood Health Study (DNHS) and tested for replication in an independent cohort of primarily European American women from the Nurses Health Study II (NHSII). We genotyped 413 DNHS women - 94 PTSD cases and 319 controls exposed to at least one traumatic event - on the Illumina HumanOmniExpress BeadChip for >700,000 markers and tested 578 PTSD cases and 1963 controls from NHSII for replication. We performed a network-based analysis integrating data from GWAS-derived independent regions of association and the Reactome database of functional interactions. We found genome-wide significant association for one marker mapping to a novel RNA gene, lincRNA AC068718.1, for which we found suggestive evidence of replication in NHSII. Our network-based analysis indicates that our top GWAS results were enriched for pathways related to telomere maintenance and immune function. Our findings implicate a novel RNA gene, lincRNA AC068718.1, as risk factor for PTSD in women and add to emerging evidence that non-coding RNA genes may play a crucial role in shaping the landscape of gene regulation with putative pathological effects that lead to phenotypic differences.
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