Evidence map›Paper›PMID 24080100›Full record

Trial reportContemporary clinical trials2013

Design features of the Diabetes and Periodontal Therapy Trial (DPTT): a multicenter randomized single-masked clinical trial testing the effect of nonsurgical periodontal therapy on glycosylated hemoglobin (HbA1c) levels in subjects with type 2 diabetes and chronic periodontitis.

DPTT study group, S Engebretson, M Gelato, L Hyman, B S Michalowicz, E Schoenfeld

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03268473 (Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03268473 nacompletednot on this mapstarted 2017, after this paper: background citation

Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in Obstructive Sleep Apnea Syndrome (OSAS)

TypeinterventionalSponsorBezmialem Vakif UniversityRan2017 to 2023Enrolled40ConditionsPeriodontitis, Obstructive Sleep Apnea, OSASArmsExperimental, Control
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Trial
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  7. Article
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  9. Review
  10. Article
  11. IPLA2 mRNA expression by human neutrophils in type 2 diabetes and chronic periodontitis.Journal of the International Academy of Periodontology · 2014
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

DPTT study group(a)New York University, College of Dentistry, New York, New York 10010, United States.
S Engebretson
M Gelato
L Hyman
B S Michalowicz
E Schoenfeld
Stony Brook University · USUniversity of Minnesota · USUniversity of York · GB

Funding

Diabetes and Periodontics Trial - Administrative Center/Study ChairU01DE018902 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI ENGEBRETSON, STEVEN P · 2008 to 2012
$11.1M
Diabetes and Periodontics Trial - Coordinating CenterU01DE018886 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI HYMAN, LESLIE G · 2008 to 2012
$4.3M
NIDCR NIH HHS U01 DE018886NIDCR NIH HHS U01 DE018902NIDCR NIH HHS UO1 DE018902
6 · The paper itself

Abstract

backgroundEvidence suggests that periodontitis is associated with prevalent and incident type 2 diabetes mellitus (T2DM), raising the question of whether periodontitis treatment may improve glycemic control in patients with T2DM. Meta-analyses of mostly small clinical trials suggest that periodontitis treatment results in a modest reduction in glycosylated hemoglobin (Hb) A1c. PURPOSE: The purpose of the Diabetes and Periodontal Therapy Trial (DPTT) was to determine if periodontal treatment reduces HbA1c in patients with T2DM and periodontitis.

methodsDPTT was a phase-III, single-masked, multi-center, randomized trial with a planned enrollment of 600 participants. Participants were randomly assigned to receive periodontal treatment immediately (Treatment Group) or after 6 months (Control Group). HbA1c values and clinical periodontal measures were determined at baseline and 3 and 6 months following randomization. Medication usage and dosing were assessed at each visit. Periodontal treatment consisted of scaling and root planing for a minimum of two 90-minute sessions, plus the use of an antibacterial mouth rinse for at least 32 days afterwards. The primary outcome was change in HbA1c from baseline to 6 months and the trial was powered to detect a between-group difference of 0.6%. Secondary outcomes included changes in periodontal clinical measures, fasting plasma glucose, the Homeostasis Model Assessment (HOMA2) and the need for rescue diabetes or periodontal therapy.

conclusionDental and medical researchers collaborated to recruit, treat and monitor participants with two chronic diseases to determine if treatment of one condition affects the status of the other.

Indexed as

Blood GlucoseClinical ProtocolsDiabetes Mellitus, Type 2Glycated HemoglobinHumansMouthwashesPeriodontitisSeverity of Illness IndexSingle-Blind MethodBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanMouthwashesDiabetes mellitusGlycosylated hemoglobinHbA1cPeriodontal diseasePeriodontitisType 2

Identifiers

PMID24080100
PMCPMC3885354
OpenAlexW2032032163

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.