ArticleNano letters2013
Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images.
Article in Nano letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 45 citations in OpenAlex.
- Classifying breast cancer and fibroadenoma tissue biopsies from paraffined stain-free slides by fractal biomarkers in Fourier Ptychographic Microscopy.Computational and structural biotechnology journal · 2024Article
- Microbes, macrophages, and melanin: a unifying theory of disease as exemplified by cancer.Frontiers in immunology · 2024Review
- Morphological profiling by high-throughput single-cell biophysical fractometry.Communications biology · 2023Article
- The Effect of Geometry and TGF-β Signaling on Tumor Cell Migration from Free-Standing Microtissues.Advanced healthcare materials · 2022Article
- Interferometric Scattering Microscopy: Seeing Single Nanoparticles and Molecules via Rayleigh Scattering.Nano letters · 2019Article
- Label-Free Imaging of Melanoma with Confocal Photothermal Microscopy: Differentiation between Malignant and Benign Tissue.Bioengineering (Basel, Switzerland) · 2018Article
- Quantitative second harmonic generation microscopy for the structural characterization of capsular collagen in thyroid neoplasms.Biomedical optics express · 2018Article
- Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma.Scientific reports · 2016Article
- Elasto-plasticity in wrinkled polymerized lipid membranes.Scientific reports · 2014Article
- Subtle Immunoreactivity Differences in the Fractal Patterns of Membrane E-Cadherin in Gastric Adenocarcinoma.Current health sciences journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotyping of tumor cells by marker-free quantification is important for cancer diagnostics. For the first time, fractal analysis of reflection interference contrast microscopy images of single living cells was employed as a new method to distinguish between different nanoscopic membrane features of tumor cells. Since tumor progression correlates with a higher degree of chaos within the cell, it can be quantified mathematically by fractality. Our results show a high accuracy in identifying malignant cells with a failure chance of 3%, which is far better than today's applied methods.
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Registered trials
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