ArticleBiomaterials2013
A biodegradable microvessel scaffold as a framework to enable vascular support of engineered tissues.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Microfluidic technologies for wearable and implantable biomedical devices.Lab on a chip · 2025Review
- Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects.Biomedical engineering online · 2025Review
- Acellular Tissue-Engineered Vascular Grafts from Polymers: Methods, Achievements, Characterization, and Challenges.Polymers · 2022Review
- Guiding cell migration in 3D with high-resolution photografting.Scientific reports · 2022Article
- Bioengineering approaches to treat the failing heart: from cell biology to 3D printing.Nature reviews. Cardiology · 2022Review
- Challenges and strategies forBioactive materials · 2021Review
- Neovascularization of engineered tissues for clinical translation: Where we are, where we should be?APL bioengineering · 2021Review
- Engineering Human Cardiac Muscle Patch Constructs for Prevention of Post-infarction LV Remodeling.Frontiers in cardiovascular medicine · 2021Review
- Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications.International journal of molecular sciences · 2019Review
- Tissue Engineering of the Microvasculature.Comprehensive Physiology · 2019Review
- Engineering stem cell cardiac patch with microvascular features representative of native myocardium.Theranostics · 2019Article
- Engineered circulatory scaffolds for building cardiac tissue.Journal of thoracic disease · 2018Review
- Vascular Network Formation by Human Microvascular Endothelial Cells in Modular Fibrin Microtissues.ACS biomaterials science & engineering · 2016Article
- Cell-microenvironment interactions and architectures in microvascular systems.Biotechnology advances · 2016Review
- Vascularization of three-dimensional engineered tissues for regenerative medicine applications.Acta biomaterialia · 2016Review
- Multi-Material Tissue Engineering Scaffold with Hierarchical Pore Architecture.Advanced functional materials · 2016Article
- Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy.Macromolecular bioscience · 2016Article
- Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis.Nature materials · 2016Article
- Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.Advanced healthcare materials · 2016Article
- Poly(Limonene Thioether) Scaffold for Tissue Engineering.Advanced healthcare materials · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
A biodegradable microvessel scaffold comprised of distinct parenchymal and vascular compartments separated by a permeable membrane interface was conceptualized, fabricated, cellularized, and implanted. The device was designed with perfusable microfluidic channels on the order of 100 μm to mimic small blood vessels, and high interfacial area to an adjacent parenchymal space to enable transport between the compartments. Poly(glycerol sebacate) (PGS) elastomer was used to construct the microvessel framework, and various assembly methods were evaluated to ensure robust mechanical integrity. In vitro studies demonstrated the differentiation of human skeletal muscle cells cultured in the parenchymal space, a 90% reduction in muscle cell viability due to trans-membrane transport of a myotoxic drug from the perfusate, and microvessel seeding with human endothelial cells. In vivo studies of scaffolds implanted subcutaneously and intraperitoneally, without or with exogenous cells, into nude rats demonstrated biodegradation of the membrane interface and host blood cell infiltration of the microvessels. This modular, implantable scaffold could serve as a basis for building tissue constructs of increasing scale and clinical relevance.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.