ArticleBMC infectious diseases2013
A prospective case-control and molecular epidemiological study of human cases of Shiga toxin-producing Escherichia coli in New Zealand.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Associating sporadic, foodborne illness caused by Shiga toxin-producing Escherichia coli with specific foods: a systematic review and meta-analysis of case-control studies.Epidemiology and infection · 2019Pooled it
- Building the Tools for Enhanced Waterway Surveillance: Prediction of Antimicrobial-ResistantJournal of the Royal Society of New Zealand · 2026Article
- Ruminant-dense environments increase risk of reported Shiga toxin-producingApplied and environmental microbiology · 2025Article
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- Ruminant-dense environments increase risk of Shiga toxin-producingmedRxiv : the preprint server for health sciences · 2024Article
- Leptospirosis in Aotearoa New Zealand: Protocol for a Nationwide Case-Control Study.JMIR research protocols · 2023Article
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- The "Big Six": Hidden Emerging Foodborne Bacterial Pathogens.Tropical medicine and infectious disease · 2022Review
- Clarification of relationship between single-nucleotide polymorphism panels of Shiga toxin-producing Escherichia coli O157:H7/H- strains.The Journal of veterinary medical science · 2022Article
- Draft Genome Sequences of 15 Multidrug-Resistant Escherichia coli Strains Isolated from Indigenous Foods and Food-Gathering Sites in Aotearoa, New Zealand.Microbiology resource announcements · 2022Article
- Whole-Genome Sequencing and Virulome Analysis of Escherichia coli Isolated from New Zealand Environments of Contrasting Observed Land Use.Applied and environmental microbiology · 2022Article
- Antibiotic resistance and phylogenetic profiling ofCurrent research in microbial sciences · 2022Article
- Detecting genes associated with antimicrobial resistance and pathogen virulence in three New Zealand rivers.PeerJ · 2021Article
- Investigation of On-Farm Transmission Routes for Contamination of Dairy Cows with Top 7 Escherichia coli O-Serogroups.Microbial ecology · 2021Article
- Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia.PloS one · 2021Article
- Investigation of the effect of chitosan and silver nanoparticles on the antibiotic resistance ofVeterinary world · 2020Article
- One Health Aotearoa: a transdisciplinary initiative to improve human, animal and environmental health in New Zealand.One health outlook · 2020Review
- Genomic epidemiology and carbon metabolism of Escherichia coli serogroup O145 reflect contrasting phylogenies.PloS one · 2020Article
- Use of Genomics to Investigate Historical Importation of Shiga Toxin-Producing Escherichia coli Serogroup O26 and Nontoxigenic Variants into New Zealand.Emerging infectious diseases · 2019Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundShiga toxin-producing Escherichia coli (STEC) O157:H7 and related non-O157 STEC strains are enteric pathogens of public health concern worldwide, causing life-threatening diseases. Cattle are considered the principal hosts and have been shown to be a source of infection for both foodborne and environmental outbreaks in humans. The aims of this study were to investigate risk factors associated with sporadic STEC infections in humans in New Zealand and to provide epidemiological information about the source and exposure pathways.
methodsDuring a national prospective case-control study from July 2011 to July 2012, any confirmed case of STEC infection notified to regional public health units, together with a random selection of controls intended to be representative of the national demography, were interviewed for risk factor evaluation. Isolates from each case were genotyped using pulsed-field gel electrophoresis (PFGE) and Shiga toxin-encoding bacteriophage insertion (SBI) typing.
resultsQuestionnaire data from 113 eligible cases and 506 controls were analysed using multivariate logistic regression. Statistically significant animal and environmental risk factors for human STEC infections were identified, notably 'Cattle livestock present in meshblock' (the smallest geographical unit) (odds ratio 1.89, 95% CI 1.04-3.42), 'Contact with animal manure' (OR 2.09, 95% CI 1.12-3.90), and 'Contact with recreational waters' (OR 2.95, 95% CI 1.30-6.70). No food-associated risk factors were identified as sources of STEC infection. E. coli O157:H7 caused 100/113 (88.5%) of clinical STEC infections in this study, and 97/100 isolates were available for molecular analysis. PFGE profiles of isolates revealed three distinctive clusters of genotypes, and these were strongly correlated with SBI type. The variable 'Island of residence' (North or South Island of New Zealand) was significantly associated with PFGE genotype (p = 0.012).
conclusionsOur findings implicate environmental and animal contact, but not food, as significant exposure pathways for sporadic STEC infections in humans in New Zealand. Risk factors associated with beef and dairy cattle suggest that ruminants are the most important sources of STEC infection. Notably, outbreaks of STEC infections are rare in New Zealand and this further suggests that food is not a significant exposure pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.