ArticleJournal of the American Chemical Society2013
Fast, label-free force spectroscopy of histone-DNA interactions in individual nucleosomes using nanopores.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Solid-state nanopore sensing: the next workhorse of biophysical characterization.Nature methods · 2026Review
- Nanopore assay for fingerprinting DNA binding and quantifying real-time cleavage by catalytically active Cas9 enzyme.Journal of nanobiotechnology · 2025Article
- Nucleosomal DNA unwinding pathway through canonical and non-canonical histone disassembly.Communications biology · 2024Article
- Time-domain event detection using single-instruction, multiple-thread gpGPU architectures in single-molecule biophysical data.Computer physics communications · 2024Article
- Aggregation and Oligomerization Characterization of ß-Lactoglobulin Protein Using a Solid-State Nanopore Sensor.Sensors (Basel, Switzerland) · 2023Article
- Accelerating biophysical studies and applications by label-free nanopore sensing.Biophysics and physicobiology · 2023Article
- Article
- Tuning Protein Discrimination Through Altering the Sampling Interface Formed between the Analyte and the OmpG Nanopore.ACS sensors · 2021Article
- A Solid-State Hard Microfluidic-Nanopore Biosensor with Multilayer Fluidics and On-Chip Bioassay/Purification Chamber.Advanced functional materials · 2018Article
- Dynamics of a Molecular Plug Docked onto a Solid-State Nanopore.The journal of physical chemistry letters · 2018Article
- Article
- DNA Translocation through Nanopores at Physiological Ionic Strengths Requires Precise Nanoscale Engineering.ACS nano · 2016Article
- Intrinsic and membrane-facilitated α-synuclein oligomerization revealed by label-free detection through solid-state nanopores.Scientific reports · 2016Article
- Article
- Nanopore sensing of individual transcription factors bound to DNA.Scientific reports · 2015Article
- Nanopores suggest a negligible influence of CpG methylation on nucleosome packaging and stability.Nano letters · 2015Article
- RNase A does not translocate the alpha-hemolysin pore.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Herein we report a novel approach for fast, label-free probing of DNA-histone interactions in individual nucleosomes. We use solid-state nanopores to unravel individual DNA/histone complexes for the first time and find that the unraveling time depends on the applied electrophoretic force, and our results are in line with previous studies that employ optical tweezers. Our approach for studying nucleosomal interactions can greatly accelerate the understanding of fundamental mechanisms by which transcription, replication, and repair processes in a cell are modulated through DNA-histone interactions, as well as in diagnosis of diseases with abnormal patterns of DNA and histone modifications.
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Registered trials
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