ArticleAnalytical chemistry2013
Analysis of the internal configurations of droplets of liquid crystal using flow cytometry.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Design of Optical Transducer for Recognition of Biomolecular Interactions between Bacterial Lipopolysaccharides and Amino Acids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fluorescence Transduction of Liquid Crystal Ordering Transitions for Biosensing.Journal of the American Chemical Society · 2026Article
- Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence.Nature communications · 2023Review
- State-of-the-Art Development in Liquid Crystal Biochemical Sensors.Biosensors · 2022Review
- Stable and Oriented Liquid Crystal Droplets Stabilized by Imidazolium Ionic Liquids.Molecules (Basel, Switzerland) · 2021Article
- Liquid Crystal-Infused Porous Polymer Surfaces: A "Slippery" Soft Material Platform for the Naked-Eye Detection and Discrimination of Amphiphilic Species.ACS applied materials & interfaces · 2021Article
- Ultrasensitive and Selective Detection of SARS-CoV-2 Using Thermotropic Liquid Crystals and Image-Based Machine Learning.Cell reports. Physical science · 2020Article
- Liquid Crystal Emulsions That Intercept and Report on Bacterial Quorum Sensing.ACS applied materials & interfaces · 2020Article
- Design and Application of Stimulus-Responsive Droplets and Bubbles Stabilized by Phospholipid Monolayers.Current opinion in colloid & interface science · 2019Article
- Tunable Gas Sensing Gels by Cooperative Assembly.Advanced functional materials · 2017Article
- Synthetic Mimics of Bacterial Lipid A Trigger Optical Transitions in Liquid Crystal Microdroplets at Ultralow Picogram-per-Milliliter Concentrations.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Reversible Switching of Liquid Crystalline Order Permits Synthesis of Homogeneous Populations of Dipolar Patchy Microparticles.Advanced functional materials · 2014Article
- Liquid crystal droplet-based amplification of microvesicles that are shed by mammalian cells.The Analyst · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
We report the use of flow cytometry to identify the internal ordering (director configurations) of micrometer-sized droplets of thermotropic liquid crystals (LCs) dispersed in aqueous solutions of adsorbates (surfactants and phospholipids). We reveal that changes in the configurations of the LC droplets induced by the adsorbates generate distinct changes in light scattering plots (side versus forward scattering). Specifically, when compared to bipolar droplets, radial droplets generate a narrower distribution of side scattering intensities (SSC, large angle light scattering) for a given intensity of forward scattering (FSC, small angle light scattering). This difference is shown to arise from the rotational symmetry of a radial LC droplet which is absent for the bipolar configuration of the LC droplet. In addition, the scatter plots for radial droplets possess a characteristic "S-shape", with two or more SSC intensities observed for each intensity of FSC. The origin of the experimentally observed S-shape is investigated via calculation of form factors and established to be due to size-dependent interference effects that differ for the forward and side scattered light. Finally, by analyzing emulsions composed of mixtures of bipolar and radial droplets at rates of up to 10,000 droplets per second, we demonstrate that flow cytometry permits precise determination of the percentage of radial droplets within the mixture with a coefficient of determination of 0.98 (as validated by optical microscopy). Overall, the results presented in this paper demonstrate that flow cytometry provides a promising approach for high throughput quantification of the internal configurations of LC emulsion microdroplets. Because large numbers of droplets can be characterized, it enables statistically robust analyses of LC droplets. The methodology also appears promising for quantification of chemical and biological assays based on adsorbate-induced ordering transitions within LC droplets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.