ArticleComputational and mathematical methods in medicine2013
Circadian models of serum potassium, sodium, and calcium concentrations in healthy individuals and their application to cardiac electrophysiology simulations at individual level.
Article in Computational and mathematical methods in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Association between postoperative changes in natremia and outcomes in patients undergoing elective craniotomy.Neurosurgical review · 2024Article
- How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology - model-based case study.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model.Biophysical journal · 2021Article
- Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.Journal of pharmacokinetics and pharmacodynamics · 2018Article
- Drug-physiology interaction and its influence on the QT prolongation-mechanistic modeling study.Journal of pharmacokinetics and pharmacodynamics · 2018Article
- Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development.Journal of pharmacokinetics and pharmacodynamics · 2018Article
- Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin.The AAPS journal · 2018Article
- Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.The AAPS journal · 2017Article
- Systems Chronotherapeutics.Pharmacological reviews · 2017Review
- Humans Vary, So Cardiac Models Should Account for That Too!Frontiers in physiology · 2017Review
- Periodic oscillations of a model for membrane permeability with fluctuating environmental conditions.Journal of mathematical biology · 2015Article
- Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information.CPT: pharmacometrics & systems pharmacology · 2014Article
- Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes.Journal of cardiovascular translational research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the article a brief description of the biological basis of the regulation of human biological clocks was presented in order to introduce the role of circadian rhythms in physiology and specifically in the pharmacological translational tools based on the computational physiology models to motivate the need to provide models of circadian fluctuation in plasma cations. The main aim of the study was to develop statistical models of the circadian rhythm of potassium, sodium, and calcium concentrations in plasma. The developed ion models were further tested by assessing their influence on QT duration (cardiac endpoint) as simulated by the biophysically detailed models of human left ventricular cardiomyocyte. The main results are model equations along with an electronic supplement to the article that contains a fully functional implementation of all models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.