ArticleNeurology2013
Fatigue in the acute phase after first stroke predicts poorer physical health 18 months later.
Article in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Remote ischaemic conditioning for neurological disorders-a systematic review and narrative synthesis.Systematic reviews · 2024Pooled it
- Association of post-stroke fatigue with physical activity and physical fitness: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- ESTREL-Fatigue-association of levodopa with post-stroke fatigue.European stroke journal · 2026Trial
- Trial
- Trial
- Prevalence and biopsychosocial predictors of post-stroke fatigue in patients with minor strokes.Journal of rehabilitation medicine · 2026Observational
- Post-Stroke Motor Fatigability: Defining and Studying the Impairments That Emerge During Prolonged Motor Tasks.Neurorehabilitation and neural repair · 2026Review
- Interrelationship between fatigue and recovery of physical function in stroke survivors: a longitudinal mixed-methods study.European journal of physical and rehabilitation medicine · 2025Article
- Neurotechnology-Based, Intensive, Supplementary Upper-Extremity Training for Inpatients With Subacute Stroke: Feasibility Study.JMIR serious games · 2025Article
- Functional Recovery in Acute and Subacute Stroke Patients With or Without Post-stroke Fatigue.Brain & NeuroRehabilitation · 2024Article
- Cortical-striatal network functional connectivity markers in poststroke fatigue: a single-centre fMRI case-control study protocol.BMJ open · 2024Article
- Causal associations of fatigue and functional outcome after ischemic stroke: a mediation Mendelian randomization study.Frontiers in neurology · 2024Article
- Factors Associated With Early and Late Post-stroke Fatigue in Patients With Mild Impairment. Results From the Stroke Cohort Study Augsburg.Frontiers in neurology · 2022Article
- "I Give It Everything for an Hour Then I Sleep for Four." The Experience of Post-stroke Fatigue During Outpatient Rehabilitation Including the Perspectives of Carers: A Qualitative Study.Frontiers in neurology · 2022Article
- Cardiorespiratory responses to exercise related to post-stroke fatigue severity.Scientific reports · 2021Article
- Post-stroke fatigue: an exploratory study with patients and health professionals to develop a patient-reported outcome measure.Journal of patient-reported outcomes · 2021Article
- Predictors and short-term outcomes of post-stroke fatigue in initial phase of transition from hospital to home: A prospective observational study.Journal of advanced nursing · 2021Observational
- Risk Factors and Imaging Mechanisms of Fatigue After Mild Ischemic Stroke: An Exploratory Study From a Single Chinese Center.Frontiers in neurology · 2021Article
- Pituitary dysfunction and association with fatigue in stroke and other acute brain injury.Endocrine connections · 2018Review
- Temporal Associations between Fatigue, Depression, and Apathy after Stroke: Results of the Cognition and Affect after Stroke, a Prospective Evaluation of Risks Study.Cerebrovascular diseases (Basel, Switzerland) · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether fatigue in the acute phase following stroke predicts long-term patient-reported physical and mental health outcomes 18 months later.
methodsPatients (n = 96, mean age 67.8 years, SD 12.9) were assessed within 2 weeks of hospital admission for first-ever stroke (acute phase) and 18 months later. Measures included the Fatigue Severity Scale and the Beck Depression Inventory II. The Short Form-36 was used to assess self-reported physical and mental health. Multivariate regression analysis was used to evaluate the relationship between acute phase fatigue and later health outcomes, controlling for relevant covariates.
resultsAcute phase fatigue was associated with physical health at 18-month follow-up, but not with mental health. After adjusting for other potential predictors of health outcomes, including age, sex, cohabitation status, acute phase physical or mental health, and depressive symptoms, acute phase fatigue remained a significant predictor of later physical health but not of later mental health. The reverse relationships were also examined, but neither physical nor mental health in the acute phase predicted fatigue at 18 months; the best predictor of fatigue at 18-month follow-up was acute phase fatigue.
conclusionsThese findings suggest that acute phase fatigue is an independent risk factor for poor physical health 18 months after stroke. Diagnosis and treatment of acute phase fatigue may improve physical health-related quality of life among stroke survivors. Effective treatments for poststroke fatigue, both in the acute phase and later in the recovery period, are needed.
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