Evidence map›Paper›PMID 24078721›Full record

Observational studyJournal of nuclear medicine : official publication, Society of Nuclear Medicine2014

Clinical Cerenkov luminescence imaging of (18)F-FDG.

Daniel L J Thorek, Christopher C Riedl, Jan Grimm

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.

  1. Guideline
  2. Compton Imaging of Ac-225 In Pre-clinical Phantoms With a 3D-positioning CZT Camera.IEEE transactions on radiation and plasma medical sciences · 2026
    Article
  3. Article
  4. Exploring innovative strides in radiolabeled nanoparticle progress for multimodality cancer imaging and theranostic applications.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  5. Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging.European journal of nuclear medicine and molecular imaging · 2024
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Detection of Shortwave-Infrared Cerenkov Luminescence from Medical Isotopes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  11. Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China.European journal of nuclear medicine and molecular imaging · 2022
    Review
  12. Observational
  13. Cerenkov Luminescence Imaging in Prostate Cancer: Not the Only Light That Shines.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Systematic imaging in medicine: a comprehensive review.European journal of nuclear medicine and molecular imaging · 2021
    Review
  18. Article
  19. Article
  20. Removal of random-valued impulse noise from Cerenkov luminescence images.Medical & biological engineering & computing · 2020
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Daniel L J ThorekDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York; and.
Christopher C Riedl
Jan Grimm
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Molecular Imaging: Training for OncologyR25CA096945 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HRICAK, HEDVIG · 2002 to 2013
$5.2M
Cerenkov-emission based nanosensors to detect biologic activities in vivoR01EB014944 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI GRIMM, JAN · 2012 to 2015
$1.6M
NCI NIH HHS 5R25CA096945-07NCI NIH HHS P30 CA008748NCI NIH HHS R25 CA096945NIBIB NIH HHS 1R01EB01494NIBIB NIH HHS R01 EB014944
6 · The paper itself

Abstract

unlabelledThe aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic (18)F-FDG scans to detect nodal disease.

methodsPatients undergoing routine (18)F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal (18)F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera.

resultsThe camera demonstrated linear correlation between activity and counts into the low nanocurie range using (18)F-FDG. Imaging of patients revealed the presence of (18)F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established.

conclusionCL imaging with diagnostic doses of (18)F-FDG is feasible and can aid in detecting disease in the clinical setting.

Indexed as

Fluorodeoxyglucose F18Cohort StudiesFemaleHumansLuminescenceMaleMiddle AgedMultimodal ImagingOptical ImagingPhotonsPilot ProjectsPositron-Emission TomographyRadiopharmaceuticalsTime FactorsTomography, X-Ray ComputedFluorodeoxyglucose F18Radiopharmaceuticals18F-FDGCerenkov luminescence imagingclinicalPET/CT

Identifiers

PMID24078721
PMCPMC3903390
OpenAlexW2164273655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.