ArticleJournal of lipid research2013
1-O-acylceramides are natural components of human and mouse epidermis.
Article in Journal of lipid research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Alterations of Ultra Long-Chain Fatty Acids in Hereditary Skin Diseases-Review Article.Frontiers in medicine · 2021Pooled it
- Impact of Ceramide Acyl Chain Length on Human Skin Barrier Recovery and Hydration.Journal of cosmetic dermatology · 2026Article
- The bioactive sphingolipid playbook. A primer for the uninitiated as well as sphingolipidologists.Journal of lipid research · 2025Review
- Don't Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies.International journal of molecular sciences · 2025Review
- Ceramides are fuel gauges on the drive to cardiometabolic disease.Physiological reviews · 2024Review
- The skin barrier: An extraordinary interface with an exceptional lipid organization.Progress in lipid research · 2023Review
- Protective Barriers Provided by the Epidermis.International journal of molecular sciences · 2023Review
- Article
- Using molecular simulation to understand the skin barrier.Progress in lipid research · 2022Review
- Stratum corneum ceramide profiles in vitro, ex vivo, and in vivo: characterization of the α-hydroxy double esterified ceramides.Analytical and bioanalytical chemistry · 2022Article
- Vegetable Butters and Oils as Therapeutically and Cosmetically Active Ingredients for Dermal Use: A Review of Clinical Studies.Frontiers in pharmacology · 2022Review
- The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis.Cells · 2021Review
- Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum.Cell biochemistry and biophysics · 2021Review
- Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS.Journal of lipid research · 2020Article
- Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols.Scientific reports · 2019Article
- Breaking the Itch-Scratch Cycle: Topical Options for the Management of Chronic Cutaneous Itch in Atopic Dermatitis.Medicines (Basel, Switzerland) · 2019Review
- A novel role for DGATs in cancer.Advances in biological regulation · 2019Review
- Long and very long lamellar phases in model stratum corneum lipid membranes.Journal of lipid research · 2019Article
- Structural and barrier properties of the skin ceramide lipid bilayer: a molecular dynamics simulation study.Journal of molecular modeling · 2019Article
- Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania.International journal for parasitology. Drugs and drug resistance · 2018Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lipid-rich stratum corneum functions as a barrier against pathogens and desiccation inter alia by an unbroken meshwork of extracellular lipid lamellae. These lamellae are composed of cholesterol, fatty acids, and ceramides (Cers) in an equimolar ratio. The huge class of skin Cers consists of three groups: group I, "classical" long and very long chain Cers; group II, ultra-long chain Cers; and group III, ω-esterified ultra-long chain Cers, which are esterified either with linoleic acid or with cornified envelope proteins and are required for the water permeability barrier. Here, we describe 1-O-acylceramides as a new class of epidermal Cers in humans and mice. These Cers contain, in both the N- and 1-O-position, long to very long acyl chains. They derive from the group I of classical Cers and make up 5% of all esterified Cers. Considering their chemical structure and hydrophobicity, we presume 1-O-acylceramides to contribute to the water barrier homeostasis. Biosynthesis of 1-O-acylceramides is not dependent on lysosomal phospholipase A2. However, glucosylceramide synthase deficiency was followed by a 7-fold increase of 1-O-acylceramides, which then contributed 30% to all esterified Cers. Furthermore, loss of neutral glucosylceramidase resulted in decreased levels of a 1-O-acylceramide subgroup. Therefore, we propose 1-O-acylceramides to be synthesized at endoplasmic reticulum-related sites.
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