ArticlePlant molecular biology2014
Isolation and functional characterization of a τ-cadinol synthase, a new sesquiterpene synthase from Lavandula angustifolia.
Article in Plant molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Genomic mechanism of aroma terpenoids biosynthesis in plants.Journal of advanced research · 2026Review
- Integrating Structural Bioinformatics and Functional Mechanisms of Sesquiterpene Synthases CARS and CADS inInternational journal of molecular sciences · 2025Article
- Mechanistic Insights into the Bornyl Diphosphate Synthase fromCurrent issues in molecular biology · 2025Article
- Review
- Construction of Simple Sequence Repeat-Based Genetic Linkage Map and Identification of QTLs for Accumulation of Floral Volatiles in Lavender (International journal of molecular sciences · 2025Article
- Transcriptome-wide investigation and functional characterization reveal a terpene synthase involved in γ-terpinene biosynthesis in Monarda citriodora.Functional & integrative genomics · 2024Article
- Terpene produced by coexpression of the TPS and P450 genes from Lavandula angustifolia protects plants from herbivore attacks during budding stages.BMC plant biology · 2023Article
- Chemical Composition and In Vitro Antioxidant Activity ofMolecules (Basel, Switzerland) · 2023Article
- Identification and characterization of novel sesquiterpene synthases TPS9 and TPS12 fromPeerJ · 2023Article
- De novo biosynthesis of τ-cadinol in engineered Escherichia coli.Bioresources and bioprocessing · 2022Article
- Short-chain isoprenyl diphosphate synthases of lavender (Lavandula).Plant molecular biology · 2020Article
- Cloning and functional characterization of a floral repressor gene from Lavandula angustifolia.Planta · 2020Article
- Quick and efficient approach to develop genomic resources in orphan species: Application in Lavandula angustifolia.PloS one · 2020Article
- RNA-Seq in the discovery of a sparsely expressed scent-determining monoterpene synthase in lavender (Lavandula).Planta · 2019Article
- Functional Analysis of Four Terpene Synthases in Rose-Scented Pelargonium Cultivars (Frontiers in plant science · 2018Article
- Isolation and functional characterization of a methyl jasmonate-responsive 3-carene synthase from Lavandula x intermedia.Plant molecular biology · 2017Article
- Article
- Functional characterization of ZmTPS7 reveals a maize τ-cadinol synthase involved in stress response.Planta · 2016Article
- Identification and Characterization of a δ-Cadinol Synthase Potentially Involved in the Formation of Boreovibrins in Boreostereum vibrans of Basidiomycota.Natural products and bioprospecting · 2016Article
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we characterize three sTPSs: a germacrene D (LaGERDS), a (E)-β-caryophyllene (LaCARS) and a τ-cadinol synthase (LaCADS). τ-cadinol synthase is reported here for the first time and its activity was studied in several biological models including transiently or stably transformed tobacco species. Three dimensional structure models of LaCADS and Ocimum basilicum γ-cadinene synthase were built by homology modeling using the template structure of Gossypium arboreum δ-cadinene synthase. The depiction of their active site organization provides evidence of the global influence of the enzymes on the formation of τ-cadinol: instead of a unique amino-acid, the electrostatic properties and solvent accessibility of the whole active site in LaCADS may explain the stabilization of the cadinyl cation intermediate. Quantitative PCR performed from leaves and inflorescences showed two patterns of expression. LaGERDS and LaCARS were mainly expressed during early stages of flower development and, at these stages, transcript levels paralleled the accumulation of the corresponding terpene products (germacrene D and (E)-β-caryophyllene). By contrast, the expression level of LaCADS was constant in leaves and flowers. Phylogenetic analysis provided informative results on potential duplication process leading to sTPS diversification in lavender.
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