ArticleEuropean journal of applied physiology2013
Acute low-load resistance exercise with and without blood flow restriction increased protein signalling and number of satellite cells in human skeletal muscle.
Article in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quantitative assessment of efficacy and evaluation of feasibility of exercise training protocols in adult and pediatric primary mitochondrial disease.BMC medicine · 2026Pooled it
- Effects of combined blood flow restriction and neuromuscular electrical stimulation on skeletal muscle hypertrophy in adults: a systematic review and meta analysis.Scientific reports · 2026Pooled it
- The Efficacy of Blood Flow Restriction Training to Improve Quadriceps Muscle Function after Anterior Cruciate Ligament Reconstruction.Medicine and science in sports and exercise · 2025Trial
- Effect of quadriceps training at different levels of blood flow restriction on quadriceps strength and thickness in the mid-term postoperative period after anterior cruciate ligament reconstruction: a randomized controlled external pilot study.BMC musculoskeletal disorders · 2023Trial
- Effects of 4 weeks of low-load unilateral resistance training, with and without blood flow restriction, on strength, thickness, V wave, and H reflex of the soleus muscle in men.European journal of applied physiology · 2017Trial
- Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin.American journal of physiology. Endocrinology and metabolism · 2014Trial
- The Effectiveness of Blood Flow Restriction Training on Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Effects of movement velocity in squat training with and without blood flow restriction.Biology of sport · 2026Article
- Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training.Sports medicine and health science · 2025Review
- An Integrated Workflow for Three-Dimensional Visualization of Human Skeletal Muscle Stem Cell Nuclei.Bio-protocol · 2025Article
- A novel short-course, low-intensity blood-flow-restricted exercise (BFRE) regimen to study satellite cell function in critical illness survivors with sustained muscle atrophy following intensive care unit-acquired weakness (ICUAW).Frontiers in physiology · 2025Article
- The effects of blood flow restriction training on post activation potentiation and fatigue level: systematic review with meta-analysis.Frontiers in physiology · 2025Review
- Acute Responses of Low-Load Resistance Exercise with Blood Flow Restriction.Journal of functional morphology and kinesiology · 2024Article
- Impact of low-load resistance exercise with and without blood flow restriction on muscle strength, endurance, and oxidative capacity: A pilot study.Physiological reports · 2024Article
- A Study to Identify the Optimum Forearm Floss Band Intensity in 29 Young Adults Performing Blood Flow Restriction Training.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Blood Flow Restriction Therapy and Its Use for Rehabilitation and Return to Sport: Physiology, Application, and Guidelines for Implementation.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Muscle Adaptations to Heavy-Load and Blood Flow Restriction Resistance Training Methods.Frontiers in physiology · 2022Article
- Blood Flow Restriction Training Using the Delfi System Is Associated With a Cellular Systemic Response.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise.European journal of applied physiology · 2020Review
- Low-load resistance training to task failure with and without blood flow restriction: muscular functional and structural adaptations.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate hypertrophic signalling after a single bout of low-load resistance exercise with and without blood flow restriction (BFR).
methodsSeven subjects performed unilateral knee extensions at 30 % of their one repetition maximum. The subjects performed five sets to failure with BFR on one leg, and then repeated the same amount of work with the other leg without BFR. Biopsies were obtained from m. vastus lateralis before and 1, 24 and 48 h after exercise.
resultsAt 1-h post-exercise, phosphorylation of p70S6KThr389 and p38MAPKThr180/Tyr182 was elevated in the BFR leg, but not in the free-flow leg. Phospho-p70S6KThr389 was elevated three- to fourfold in both legs at 24-h post-exercise, but back to baseline at 48 h. The number of visible satellite cells (SCs) per muscle fibre was increased for all post-exercise time points and in both legs (33–53 %). The proportion of SCs with cytoplasmic extensions was elevated at 1-h post in the BFR leg and the number of SCs positive for myogenin and/or MyoD was increased at 1- and 24-h post-exercise for both legs combined.
conclusionAcute low-load resistance exercise with BFR resulted in early (1 h) and late (24 h) enhancement of phospho-p70S6KThr389, an early response of p38MAPK, and an increased number of SCs per muscle fibre. Enhanced phospho-p70S6KThr389 at 24-h post-exercise and increases in SC numbers were seen also in the free-flow leg. Implications of these findings for the hypertrophic effects of fatiguing low-load resistance exercise with and without BFR are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.