ReviewCurrent pain and headache reports2013
The perception of pain and its management in disorders of consciousness.
Review in Current pain and headache reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Improvement in the Cognitive Function in Chronic Pain: Therapeutic Potential of the Endocannabinoid System.Molecular neurobiology · 2025Review
- Reconfiguring Pain Interpretation Within a Social Model of Health Using a Simplified Version of Wilber's All Quadrant All Levels Framework: An Integral Vision.Behavioral sciences (Basel, Switzerland) · 2025Article
- Empirical comparison of deep learning models for fNIRS pain decoding.Frontiers in neuroinformatics · 2024Article
- Study protocol: Developing telephone follow-up scale for patients with disorders of consciousness.Frontiers in public health · 2023Article
- Towards a New Assessment Tool for Caregivers of Patients with Disorders of Consciousness: The Social and Family Evaluation Scale (SAFE).Brain sciences · 2022Article
- Pain in Persons with Disorders of Consciousness.Brain sciences · 2022Review
- The Integration of Assistive Technology and Virtual Reality for Assessment and Recovery of Post-coma Patients With Disorders of Consciousness: A New Hypothesis.Frontiers in psychology · 2022Article
- The influence of the CRS-R score on functional outcome in patients with severe brain injury receiving early rehabilitation.BMC neurology · 2021Article
- Consciousness Beyond Neural Fields: Expanding the Possibilities of What Has Not Yet Happened.Frontiers in psychology · 2021Article
- Effects of intrathecal baclofen therapy in subjects with disorders of consciousness: a reappraisal.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Disorders of Consciousness: Painless or Painful Conditions?-Evidence from Neuroimaging Studies.Brain sciences · 2016Review
- An Innovative Model of a Home-Like Environment for People in Vegetative and Minimally Conscious States.The Neurohospitalist · 2016Article
- Intrathecal baclofen: effects on spasticity, pain, and consciousness in disorders of consciousness and locked-in syndrome.Current pain and headache reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most controversial issues in the management of patients in a vegetative state or a minimally conscious state concerns their hypothetical capacity to continue to experience pain despite an apparent absence of self- and environmental awareness. Recent functional neuroimaging studies have shown a greater perception of pain in patients in minimally conscious state compared with patients in vegetative state, suggesting the possible involvement of preserved cognitive mechanisms in the process of pain modulation in the former. In addition, a subgroup of patients might continue to experience some elementary emotional and affective feelings, as suggested by the reported activation of specific cerebral areas in response to situations, which commonly generate empathy. However, the available evidence is not sufficient to draw conclusions about the presence or absence of pain experience in patients with disorders of consciousness. Future studies should contribute to a better understanding of which central neural pathways are involved in the perception and modulation of pain in healthy subjects and in patients with severe brain injuries. Such studies should thus also improve our know-how about pain management in this particularly challenging group of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.