ArticleEuropean radiology2014
Time-resolved assessment of collateral flow using 4D CT angiography in large-vessel occlusion stroke.
Article in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Collateral status and tissue outcome after intra-arterial therapy for patients with acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Trial
- Trial
- Differentiating effective salvage from ineffective delayed compensation in anterior circulation stroke: a dynamic quantitative collateral index.Frontiers in medicine · 2026Article
- Dual-phase CTA filling pattern is associated with reperfusion-related complications after mechanical thrombectomy in late-window anterior circulation stroke.Frontiers in medicine · 2026Article
- Article
- Perfusion Parameter Map Generation from 3 Phases of Computed Tomography Perfusion in Stroke Using Generative Adversarial Networks.Research (Washington, D.C.) · 2025Article
- Deep learning-assisted diagnosis of large vessel occlusion in acute ischemic stroke based on four-dimensional computed tomography angiography.Frontiers in neuroscience · 2024Article
- The image quality and diagnostic performance of CT perfusion-derived CT angiography versus that of conventional CT angiography.Quantitative imaging in medicine and surgery · 2023Article
- Systematic Analysis of RNA Expression Profiles in Different Ischemic Cortices in MCAO Mice.Cellular and molecular neurobiology · 2023Article
- MR Angiography in Assessment of Collaterals in Patients with Acute Ischemic Stroke: A Comparative Analysis with Digital Subtraction Angiography.Brain sciences · 2022Article
- Merging Multiphase CTA Images and Training Them Simultaneously with a Deep Learning Algorithm Could Improve the Efficacy of AI Models for Lateral Circulation Assessment in Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2022Article
- Evolution of Hypodensity on Non-Contrast CT in Correlation with Collaterals in Anterior Circulation Stroke with Successful Endovascular Reperfusion.Journal of clinical medicine · 2022Article
- Preliminary Application of a Quantitative Collateral Assessment Method in Acute Ischemic Stroke Patients With Endovascular Treatments: A Single-Center Study.Frontiers in neurology · 2021Article
- Evaluating the Velocity and Extent of Cortical Venous Filling in Patients With Severe Middle Cerebral Artery Stenosis or Occlusion.Frontiers in neurology · 2021Article
- Automatic collateral circulation scoring in ischemic stroke using 4D CT angiography with low-rank and sparse matrix decomposition.International journal of computer assisted radiology and surgery · 2020Article
- Single Centre Experience on Decision Making for Mechanical Thrombectomy Based on Single-Phase CT Angiography by Including NCCT and Maximum Intensity Projection Images - A Comparison with Magnetic Resonance Imaging after Non-Contrast CT.Journal of Korean Neurosurgical Society · 2020Article
- Collateral perfusion using arterial spin labeling in symptomatic versus asymptomatic middle cerebral artery stenosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Single-phase CT angiography: collateral grade is independent of scan weighting.Neuroradiology · 2019Article
- Outcome Prediction Using Perfusion Parameters and Collateral Scores of Multi-Phase and Single-Phase CT Angiography in Acute Stroke: Need for One, Two, Three, or Thirty Scans?Journal of stroke · 2018Article
- Internal Carotid Artery Stenosis and Collateral Recruitment in Stroke Patients.Clinical neuroradiology · 2018Observational
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Authors and funding
8 authors.
Funding
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Abstract
objectivesIn acute stroke patients with large vessel occlusion, collateral blood flow affects tissue fate and patient outcome. The visibility of collaterals on computed tomography angiography (CTA) strongly depends on the acquisition phase, but the optimal time point for collateral imaging is unknown.
methodsWe analysed collaterals in a time-resolved fashion using four-dimensional (4D) CTA in 82 endovascularly treated stroke patients, aiming to determine which acquisition phase best depicts collaterals and predicts outcome. Early, peak and late phases as well as temporally fused maximum intensity projections (tMIP) were graded using a semiquantitative regional leptomeningeal collateral score, compared with conventional single-phase CTA and correlated with functional outcome.
resultsThe total extent of collateral flow was best visualised on tMIP. Collateral scores were significantly lower on early and peak phase as well as on single-phase CTA. Collateral grade was associated with favourable functional outcome and the strength of this relationship increased from earlier to later phases, with collaterals on tMIP showing the strongest correlation with outcome.
conclusionsTemporally fused tMIP images provide the best depiction of collateral flow. Our findings suggest that the total extent of collateral flow, rather than the velocity of collateral filling, best predicts clinical outcome. KEY POINTS: • Collateral flow visibility on CTA strongly depends on the acquisition phase • tMIP offers the best visualisation of the extent of collaterals • Outcome prediction may be better with tMIP than with earlier phases.• Total extent of collaterals seems more important than their filling speed • If triggered too early, CTA may underestimate collateral flow.
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