Evidence map›Paper›PMID 24077997›Full record

ArticleSurgery today2014

Diagnostic value of ¹⁸F-FDG PET/CT for lymph node metastasis of esophageal squamous cell carcinoma.

Hiroyuki Yamada, Masao Hosokawa, Kazuo Itoh, Toshinao Takenouchi, Yoshihiro Kinoshita, Tomohiro Kikkawa, Keita Sakashita, Shion Uemura, Yasunori Nishida, Takaya Kusumi and 1 more

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In one paragraph

Article in Surgery today, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. The efficiency ofBMC cancer · 2021
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  11. Modified method to improve the diagnostic efficiency ofAnnals of translational medicine · 2021
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  12. Review
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  14. Role of precision imaging in esophageal cancer.Journal of thoracic disease · 2020
    Review
  15. International journal of clinical and experimental pathology · 2019
    Article
  16. Article
  17. Article
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  19. Article
  20. Tubular adenoma of the common bile duct with uptake inMolecular and clinical oncology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hiroyuki Yamada
Masao Hosokawa
Kazuo Itoh
Toshinao Takenouchi
Yoshihiro Kinoshita
Tomohiro Kikkawa
Keita Sakashita
Shion Uemura
Yasunori Nishida
Takaya Kusumi
Shigeyuki Sasaki

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study investigated the diagnostic accuracy of hybrid positron-emission tomography/computed tomography (PET/CT) for lymph node (LN) metastasis of esophageal cancer. We also investigated the correlation between the size of metastatic nests and the detection by PET/CT.

methodsTwo hundred and fifty-eight patients with esophageal squamous cell carcinoma who underwent esophagectomy with two- or three-field radical lymphadenectomy were analyzed retrospectively. We compared the diagnosis of preoperative PET/CT to the postoperative histopathological examination by each anatomical field (n = 1,231) in all 258 patients. The metastatic LNs resected from PET/CT positive fields were classified as belonging to the PET/CT-N-positive group (n = 229) and those from negative fields as belonging to the PET/CT-N-negative group (n = 352). The cross-sectional areas of metastatic nests were measured in each metastatic LN.

resultsOf the 1,231 fields, 275 (22 %) were positive for metastasis, including 581 LNs from 408 regional LN stations. The sensitivity and specificity of PET/CT examined by each anatomical field were 25.8 and 97.8 %, respectively. The median area of metastatic nests was 17.7 mm2 in the PET/CT-N-positive group, and 7.7 mm2 in the PET/CT-N-negative group (p < 0.001).

conclusionsA significant correlation was suggested between the nest size and detection by PET/CT. Because of its low sensitivity, PET/CT alone is insufficient to determine the surgical procedures, especially when considering reduction surgery.

Indexed as

Fluorine RadioisotopesFluorodeoxyglucose F18RadiopharmaceuticalsAdultAgedAged, 80 and overCarcinoma, Squamous CellEsophageal NeoplasmsFemaleHumansLymphatic MetastasisMaleMiddle AgedPositron-Emission TomographyRetrospective StudiesSensitivity and SpecificityFluorine RadioisotopesFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.