ArticlePediatric nephrology (Berlin, Germany)2014
Carotid intima media thickness, oxidative stress, and inflammation in children with chronic kidney disease.
Article in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A systematic review for the efficacy of coenzyme Q10 in patients with chronic kidney disease.International urology and nephrology · 2022Pooled it
- PROGRESS Study: Longitudinal analysis of antioxidant status and its relationship with heat shock proteins in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2026Article
- Mechanisms underlying atrial fibrillation in chronic kidney disease.Journal of molecular and cellular cardiology · 2025Review
- Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging.Archives of toxicology · 2023Review
- Systemic Inflammation, Oxidative Stress and Cardiovascular Health in Children and Adolescents: A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Chronic kidney disease in the pathogenesis of acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Oxidative stress in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency.Experimental and therapeutic medicine · 2019Article
- Assessment of Carotid Intima-Media Thickness as an Early Marker Of Vascular Damage In Hypertensive Children.Arquivos brasileiros de cardiologia · 2017Observational
- Oxidative stress and cardiac dysfunction in children with chronic renal failure on regular hemodialysis.Pediatric nephrology (Berlin, Germany) · 2016Article
- The Biology of Hemodialysis Vascular Access Failure.Seminars in interventional radiology · 2016Review
- HDL in children with CKD promotes endothelial dysfunction and an abnormal vascular phenotype.Journal of the American Society of Nephrology : JASN · 2014Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe evaluated the association between inflammation and oxidative stress with carotid intima media thickness (cIMT) and elasticity increment module (E(inc)) in pediatric patients with chronic kidney disease (CKD).
methodsThis analytical, cross-sectional study assessed 134 children aged 6-17 years with CKD. Anthropometric measurements and biochemistry of intact parathyroid hormone (iPTH), high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, IL-1β, reduced glutathione (GSH), malondialdehyde, nitric oxide, and homocysteine were recorded. Bilateral carotid ultrasound (US) was taken. Patients were compared with controls for cIMT and E(inc) using ≥ 75 percentile (PC).
resultsMean cIMT was 0.528 ± 0.089 mm; E(inc) was 0.174 ± 0.121 kPa × 10(3); cIMT negatively correlated with phosphorus (r -0.19, p =0.028) and the calcium × phosphorus (Ca × P) product (r -0.26, p =0.002), and positively with iPTH (r 0.19,p =0.024). After adjusting for potential confounders, hemodialysis (HD) (β=0.111, p =<0.001), automated peritoneal dialysis (APD) (β=0.064, p =0.026), and Ca x P product(β=-0.002, p =0.015) predicted cIMT (R(2)=0.296). In patients on dialysis, HD (β=0.068, p =0.010), low-density lipoprotein cholesterol (LDL-C) (β=0.001, p =0.048), and GSH(β=-0.0001, p=0.041) independently predicted cIMT (R(2)=0.204); HD, hypoalbuminemia, and high iPTH increased the risk of increased cIMT. In dialysis, E(inc) was inversely associated with GSH, and in predialysis, Ca × P correlated with/predicted E(inc) (β=0.001, p =0.009).
conclusionscIMT and E(inc) strongly associate with several biochemical parameters and GSH but not with other oxidative stress or inflammation markers.
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