Evidence map›Paper›PMID 24077615›Full record

ReviewReviews in the neurosciences2013

The role of the actin cytoskeleton in regulating Drosophila behavior.

Shamsideen A Ojelade, Summer F Acevedo, Adrian Rothenfluh

Abstract readReview
In one paragraph

Review in Reviews in the neurosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Neuronal Actin Remodeling and Its Role in Higher Nervous Activity.International journal of molecular sciences · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shamsideen A Ojelade
Summer F Acevedo
Adrian Rothenfluh

Funding

Basic Science Training Program in Drug Abuse ResearchT32DA007290 · NIDA · YALE UNIVERSITY · PI SELF, DAVID W · 1992 to 2017
$6.7M
Control of Alcohol Responses by Actin-Regulating GenesR01AA019526 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHENFLUH, ADRIAN · 2010 to 2025
$5.4M
Role of icarus in ethanol-induced behaviorsF31AA021340 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI OJELADE, SHAMSIDEEN A · 2012 to 2013
$59k
NIAAA NIH HHS F31-AA021340NIAAA NIH HHS R01 AA019526NIDA NIH HHS T32 DA 7290
6 · The paper itself

Abstract

Over the past decade, the function of the cytoskeleton has been studied extensively in developing and mature neurons. Actin, a major cytoskeletal protein, is indispensable for the structural integrity and plasticity of neurons and their synapses. Disruption of actin dynamics has significant consequence for neurons, neuronal circuits, and the functions they govern. In particular, cell adhesion molecules, members of the Rho family of GTPases, and actin-binding proteins are important modulators of actin dynamics and neuronal as well as behavioral plasticity. In this review, we discuss recent advances in Drosophila that highlight the importance of actin regulatory proteins in mediating fly behaviors such as circadian rhythm, courtship behavior, learning and memory, and the development of drug addiction.

Indexed as

Actin CytoskeletonAnimalsBehavior, AnimalCell Adhesion MoleculesDrosophilaFragile X Messenger Ribonucleoprotein 1rho GTP-Binding ProteinsSynapsesCell Adhesion MoleculesFragile X Messenger Ribonucleoprotein 1rho GTP-Binding Proteins

Identifiers

PMID24077615
PMCPMC4059371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.