ArticleNature neuroscience2013
Equalization of odor representations by a network of electrically coupled inhibitory interneurons.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Photomapping electrically coupled networks of the mature thalamus and cortex.Science advances · 2026Article
- Representational learning by optimization of neural manifolds in an olfactory memory network.Nature neuroscience · 2026Article
- Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.The Journal of physiology · 2026Article
- Photomapping electrically coupled networks of the mature thalamus and cortex.bioRxiv : the preprint server for biology · 2026Article
- Enhanced multisensory integration in the olfactory bulb of the Mexican cavefish.bioRxiv : the preprint server for biology · 2026Article
- Order code in the olfactory system.bioRxiv : the preprint server for biology · 2025Article
- Structural Regeneration and Functional Recovery of the Olfactory System of Adult Zebrafish Following Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2025Article
- Article
- The primacy model and the structure of olfactory space.PLoS computational biology · 2024Article
- Normative and mechanistic model of an adaptive circuit for efficient encoding and feature extraction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- Identification of a GABAergic neuroblast lineage modulating sweet and bitter taste sensitivity.Current biology : CB · 2022Article
- On the Diverse Functions of Electrical Synapses.Frontiers in cellular neuroscience · 2022Review
- Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Circumventing neural damage in a C. elegans chemosensory circuit using genetically engineered synapses.Cell systems · 2021Article
- Paradoxically Sparse Chemosensory Tuning in Broadly Integrating External Granule Cells in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Whitening of odor representations by the wiring diagram of the olfactory bulb.Nature neuroscience · 2020Article
- Fully Printed Geranium-Inspired Encapsulated Arrays for Quantitative Odor Releasing.ACS omega · 2019Article
- Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area.Nature neuroscience · 2019Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Robustness of neuronal activity patterns against variations in input intensity is critical for neuronal computations. We found that odor representations in the olfactory bulb were stabilized by interneurons that were densely coupled to the output neurons by electrical and GABAergic synapses. This interneuron network modulated responses of output neurons as a function of stimulus intensity in two ways: it globally boosted responses to weak odors, but attenuated responses to strong odors, and it increased the sensitivity of some output neurons, but decreased the sensitivity of others. These effects are closely related to strategies used in engineering to increase dynamic range. Together, they maintained not only the mean, but also the distribution, of activity across the population of output neurons within narrow limits, which is important for pattern classification. Neuronal circuits in the olfactory bulb therefore stabilize combinatorial sensory representations against variations in stimulus intensity by generic mechanisms.
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