Evidence map›Paper›PMID 24077434›Full record

Trial reportJournal of Alzheimer's disease : JAD2014

A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease.

Lynne Shinto, Joseph Quinn, Thomas Montine, Hiroko H Dodge, William Woodward, Sara Baldauf-Wagner, Dana Waichunas, Lauren Bumgarner, Dennis Bourdette, Lisa Silbert and 1 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00090402 (Fish Oil and Alpha Lipoic Acid in Mild Alzheimer's Disease), which is not on this map. Cited by 145 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 17 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00090402 phase1 / phase2completednot on this map

Fish Oil and Alpha Lipoic Acid in Mild Alzheimer's Disease

TypeinterventionalSponsorOregon Health and Science UniversityRan2004 to 2007Enrolled39ConditionsAlzheimer's Disease, Oxidative Stress, Dementia, HyperlipidemiaArmsFish Oil, Lipoic Acid, Fish Oil Placebo, Lipoic Acid Placebo
3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 17 syntheses or guidelines pooled it, 282 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Omega-3 fatty acids for the treatment of dementia.The Cochrane database of systematic reviews · 2016
    Pooled it
  18. Article
  19. Article
  20. Review

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lynne ShintoDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Joseph Quinn
Thomas Montine
Hiroko H Dodge
William Woodward
Sara Baldauf-Wagner
Dana Waichunas
Lauren Bumgarner
Dennis Bourdette
Lisa Silbert
Jeffrey Kaye
Oregon Health & Science University · USUniversity of Washington · US

Funding

OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
YOUTH, Osteoporosis, and Understanding Total Health (YOUTH)M01RR000334 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI DORSA, DANIEL MICHAEL · 1985 to 2006
$30.6M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 1990 to 2019
$27.7M
Fish oil &alpha lipoic acid in mild Alzheimer's diseaseR21AG023805 · NIA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI SHINTO, LYNNE H · 2003 to 2004
$359k
NCRR NIH HHS M01 RR000334NCRR NIH HHS M01RR00334NCRR NIH HHS UL1 RR024140NIA NIH HHS AG08017NIA NIH HHS P30 AG008017NIA NIH HHS R21 AG023805NIA NIH HHS R21AG023805
6 · The paper itself

Abstract

Oxidative stress, inflammation, and increased cholesterol levels are all mechanisms that have been associated with Alzheimer's disease (AD) pathology. Several epidemiologic studies have reported a decreased risk of AD with fish consumption. This pilot study was designed to evaluate the effects of supplementation with omega-3 fatty acids alone (ω-3) or omega-3 plus alpha lipoic acid (ω-3 + LA) compared to placebo on oxidative stress biomarkers in AD. The primary outcome measure was peripheral F2-isoprostane levels (oxidative stress measure). Secondary outcome measures included performance on: Mini-Mental State Examination (MMSE), Activities of Daily Living/Instrumental Activities of Daily Living (ADL/IADL), and Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-cog). Thirty-nine AD subjects were randomized to one of three groups: 1) placebo, 2) ω-3, or 3) ω-3 + LA for a treatment duration of 12 months. Eighty seven percent (34/39) of the subjects completed the 12-month intervention. There was no difference between groups at 12 months in peripheral F2-isoprostane levels (p = 0.83). The ω-3 + LA and ω-3 were not significantly different than the placebo group in ADAS-cog (p = 0.98, p = 0.86) and in ADL (p = 0.15, p = 0.82). Compared to placebo, the ω-3 + LA showed less decline in MMSE (p < 0.01) and IADL (p = 0.01) and the ω-3 group showed less decline in IADL (p < 0.01). The combination of ω-3 + LA slowed cognitive and functional decline in AD over 12 months. Because the results were generated from a small sample size, further evaluation of the combination of omega-3 fatty acids plus alpha-lipoic acid as a potential treatment in AD is warranted.

Indexed as

Activities of Daily LivingAgedAged, 80 and overAlzheimer DiseaseAnalysis of VarianceCognition DisordersDouble-Blind MethodF2-IsoprostanesFatty Acids, Omega-3FemaleHumansMaleMental Status ScheduleMiddle AgedOutcome Assessment, Health CarePilot ProjectsF2-IsoprostanesFatty Acids, Omega-3Thioctic AcidAlpha-lipoic acidAlzheimer's diseaseclinical trialomega-3 fatty acids

Identifiers

PMID24077434
PMCPMC3886557
OpenAlexW1528771930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.