ArticleScientific reports2013
A serotonin-induced N-glycan switch regulates platelet aggregation.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta.The Journal of biological chemistry · 2016Trial
- GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- The Coordinated Changes in Platelet Glycan Patterns with Blood Serotonin and Exosomes.International journal of molecular sciences · 2024Review
- Serotonin Signaling and the Hyperpermeable Endothelial Barrier in Sepsis: Clues to a Molecular Mechanism.Journal of community medicine & public health · 2024Article
- Lipids regulate peripheral serotonin release via gut CD1d.Immunity · 2023Article
- Multichannel Recovery Potential with Activated Autologous Intraovarian Platelet-Rich Plasma and Its Derivatives.Medicines (Basel, Switzerland) · 2023Article
- Parallel pathways for serotonin biosynthesis and metabolism in C. elegans.Nature chemical biology · 2023Article
- Exploring the mechanism of traditional Chinese medicine in regulating gut-derived 5-HT for osteoporosis treatment.Frontiers in endocrinology · 2023Review
- Toward Elucidating the Human Gut Microbiota-Brain Axis: Molecules, Biochemistry, and Implications for Health and Diseases.Biochemistry · 2022Review
- Serotonin: a platelet hormone modulating cardiovascular disease.Journal of thrombosis and thrombolysis · 2021Review
- Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.Immunity · 2021Article
- Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD.Life (Basel, Switzerland) · 2020Article
- Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity.MicrobiologyOpen · 2019Review
- Intestinal Flora Disruption and Novel Biomarkers Associated With Nasopharyngeal Carcinoma.Frontiers in oncology · 2019Article
- Responses of Plasma Catecholamine, Serotonin, and the Platelet Serotonin Transporter to Cigarette Smoking.Frontiers in neuroscience · 2019Review
- Blood plasma/IgG N-glycome biosignatures associated with major depressive disorder symptom severity and the antidepressant response.Scientific reports · 2018Article
- Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples.Frontiers in neuroscience · 2018Article
- Thrombosis in Thyroid Cancer.International journal of endocrinology and metabolism · 2018Review
- Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice.Frontiers in microbiology · 2018Article
- Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.Journal of cellular physiology · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Serotonin (5-HT) is a multifunctional signaling molecule that plays different roles in a concentration-dependent manner. We demonstrated that elevated levels of plasma 5-HT accelerate platelet aggregation resulting in a hypercoagulable state in which the platelet surface becomes occupied by several glycoproteins. Here we study the novel hypothesis that an elevated level of plasma 5-HT results in modification of the content of N-glycans on the platelet surface and this abnormality is associated with platelet aggregation. Mass spectrometry of total surface glycoproteins on platelets isolated from wild-type mice infused for 24 hours with saline or 5-HT revealed that the content of glycoproteins on platelets from 5-HT-infused mice switched from predominantly N-acetyl-neuraminic acid (Neu5Ac) to N-glycolyl-neuraminic acid (Neu5Gc). Cytidine monophosphate-N-acetylneuraminate hydroxylase (CMAH) synthesizes Neu5Gc from Neu5Ac. Up-regulation of Neu5Gc content on the platelet surface resulted from an increase in the catalytic function, not expression, of CMAH in platelets of 5-HT-infused mice. The highest level of Neu5Gc was observed in platelets of 5-HT-infused, 5-HT transporter-knock out mice, suggesting that the surface delineated 5-HT receptor on platelets may promote CMAH catalytic activity. These new findings link elevated levels of plasma 5-HT to altered platelet N-glycan content, a previously unrecognized abnormality that may favor platelet aggregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.