ArticleGenetics2013
Regulation of Toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- A dynamic Dif/lncRNA-CR42715/miR-965-3p feedback loop orchestrates toll pathway immunity response in Drosophila.PLoS pathogens · 2026Article
- Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling.PLoS pathogens · 2024Article
- SUMOylation of Dorsal attenuates Toll/NF-κB signaling.Genetics · 2022Article
- Mutations ofInternational journal of molecular sciences · 2022Article
- The incidence of candidate binding sites for β-arrestin in Drosophila neuropeptide GPCRs.PloS one · 2022Article
- Article
- Drosophila H2Av negatively regulates the activity of the IMD pathway via facilitating Relish SUMOylation.PLoS genetics · 2021Article
- The role of SUMOylation during development.Biochemical Society transactions · 2020Review
- The Physical Mechanisms ofGenetics · 2020Article
- Review
- Structure-function analysis of β-arrestin Kurtz reveals a critical role of receptor interactions in downregulation of GPCR signaling in vivo.Developmental biology · 2019Article
- Transcriptomic analysis of immune response to bacterial lipopolysaccharide in zebra finch (Taeniopygia guttata).BMC genomics · 2019Article
- Article
- Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.Science signaling · 2018Article
- The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer.Journal of developmental biology · 2018Review
- Medium-scale Preparation of Drosophila Embryo Extracts for Proteomic Experiments.Journal of visualized experiments : JoVE · 2017Article
- SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling.Scientific reports · 2017Article
- β-Arrestins Negatively Regulate the Toll Pathway in Shrimp by Preventing Dorsal Translocation and Inhibiting Dorsal Transcriptional Activity.The Journal of biological chemistry · 2016Article
- SUMO-Enriched Proteome for Drosophila Innate Immune Response.G3 (Bethesda, Md.) · 2015Article
- The immune signaling pathways of Manduca sexta.Insect biochemistry and molecular biology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The Toll signaling pathway has a highly conserved function in innate immunity and is regulated by multiple factors that fine tune its activity. One such factor is β-arrestin Kurtz (Krz), which we previously implicated in the inhibition of developmental Toll signaling in the Drosophila melanogaster embryo. Another level of controlling Toll activity and immune system homeostasis is by protein sumoylation. In this study, we have uncovered a link between these two modes of regulation and show that Krz affects sumoylation via a conserved protein interaction with a SUMO protease, Ulp1. Loss of function of krz or Ulp1 in Drosophila larvae results in a similar inflammatory phenotype, which is manifested as increased lamellocyte production; melanotic mass formation; nuclear accumulation of Toll pathway transcriptional effectors, Dorsal and Dif; and expression of immunity genes, such as Drosomycin. Moreover, mutations in krz and Ulp1 show dosage-sensitive synergistic genetic interactions, suggesting that these two proteins are involved in the same pathway. Using Dorsal sumoylation as a readout, we found that altering Krz levels can affect the efficiency of SUMO deconjugation mediated by Ulp1. Our results demonstrate that β-arrestin controls Toll signaling and systemic inflammation at the level of sumoylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.