ArticleGenetics2013
Noncoding RNAs of the Ultrabithorax domain of the Drosophila bithorax complex.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A Synergistic, Cultivator Model of De Novo Gene Origination.Genome biology and evolution · 2024Article
- Article
- Blocking the blocker.eLife · 2023Article
- lncRNA read-through regulates the BX-C insulatoreLife · 2023Article
- Recent Advances and Future Potential of Long Non-Coding RNAs in Insects.International journal of molecular sciences · 2023Review
- Pleiotropic fitness effects of the lncRNA Uhg4 in Drosophila melanogaster.BMC genomics · 2022Article
- Article
- Article
- Long Non-Coding RNAs in Insects.Animals : an open access journal from MDPI · 2021Review
- Mapping of functional elements of the Fab-6 boundary involved in the regulation of the Abd-B hox gene in Drosophila melanogaster.Scientific reports · 2021Article
- Molecular Lessons from theGenetics · 2020Review
- Insights into the Functions of LncRNAs inInternational journal of molecular sciences · 2019Review
- Transcription through Polycomb response elements does not induce a switch from repression to activation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior.Mechanisms of development · 2015Review
- Neural functions of long noncoding RNAs in Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- The open for business model of the bithorax complex in Drosophila.Chromosoma · 2015Review
- Review
- H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex.eLife · 2014Article
- Regulation of transcription by long noncoding RNAs.Annual review of genetics · 2014Review
- Regulation of gene expression in the genomic context.Computational and structural biotechnology journal · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
RNA transcripts without obvious coding potential are widespread in many creatures, including the fruit fly, Drosophila melanogaster. Several noncoding RNAs have been identified within the Drosophila bithorax complex. These first appear in blastoderm stage embryos, and their expression patterns indicate that they are transcribed only from active domains of the bithorax complex. It has been suggested that these noncoding RNAs have a role in establishing active domains, perhaps by setting the state of Polycomb Response Elements A comprehensive survey across the proximal half of the bithorax complex has now revealed nine distinct noncoding RNA transcripts, including four within the Ultrabithorax transcription unit. At the blastoderm stage, the noncoding transcripts collectively span ∼75% of the 135 kb surveyed. Recombination-mediated cassette exchange was used to invert the promoter of one of the noncoding RNAs, a 23-kb transcript from the bxd domain of the bithorax complex. The resulting animals fail to make the normal bxd noncoding RNA and show no transcription across the bxd Polycomb Response Element in early embryos. The mutant flies look normal; the regulation of the bxd domain appears unaffected. Thus, the bxd noncoding RNA has no apparent function.
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Registered trials
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