Evidence map›Paper›PMID 24077239›Full record

ReviewNutrients2013

Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders.

Carlo Catassi, Julio C Bai, Bruno Bonaz, Gerd Bouma, Antonio Calabrò, Antonio Carroccio, Gemma Castillejo, Carolina Ciacci, Fernanda Cristofori, Jernej Dolinsek and 16 more

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 166 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 3 pooled it
43.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02248545 completednot on this map

Autoimmune Diseases And Serum Anti-Nuclear Antibodies Positivity In Non-Celiac Wheat Sensitivity Patients

TypeobservationalSponsorUniversity of PalermoRan2011 to 2014Enrolled90ConditionsNon-Celiac Wheat Sensitivity
NCT02431585 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Prevalence of Gluten Sensitivity in Irritable Bowel Syndrome: The First Study in Paediatrics. (GS-IBS)

TypeinterventionalSponsorUniversity of BariRan2015 to 2015Enrolled100ConditionsIrritable Bowel Syndrome, Gluten SensitivityArmsgluten, placebo
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 3 syntheses or guidelines pooled it, 490 citations in OpenAlex.

  1. Comparison of gut microbiota profile in celiac disease, non-celiac gluten sensitivity and irritable bowel syndrome: A systematic review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020
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  3. Microscopic enteritis: Bucharest consensus.World journal of gastroenterology · 2015
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 20 institutions in 9 countries.

Carlo CatassiDepartment of Pediatrics, Università Politecnica delle Marche, Ancona 60121, Italy. afasano@partners.org.
Julio C Bai
Bruno Bonaz
Gerd Bouma
Antonio Calabrò
Antonio Carroccio
Gemma Castillejo
Carolina Ciacci
Fernanda Cristofori
Jernej Dolinsek
Ruggiero Francavilla
Luca Elli
Peter Green
Wolfgang Holtmeier
Peter Koehler
Sibylle Koletzko
Christof Meinhold
David Sanders
Michael Schumann
Detlef Schuppan
Reiner Ullrich
Andreas Vécsei
Umberto Volta
Victor Zevallos
Anna Sapone
Alessio Fasano
Charité - Universitätsmedizin Berlin · DEUniversity of Bari Aldo Moro · ITBeth Israel Deaconess Medical Center · USCentre Hospitalier Universitaire de Grenoble · FRColumbia University Irving Medical Center · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHospital Universitari Sant Joan de Reus · ESJohannes Gutenberg University Mainz · DEKrankenhaus Porz am Rhein · DELeibniz-Institute for Food Systems Biology at the Technical University of Munich · DEMarche Polytechnic University · ITMassachusetts General Hospital · USRoyal Hallamshire Hospital · GBSt Anna Children's Hospital · ATUniversity Clinical Centre Maribor · SIUniversity of Bologna · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Florence · ITUniversity of Palermo · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non Celiac Gluten sensitivity (NCGS) was originally described in the 1980s and recently a "re-discovered" disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected with either celiac disease (CD) or wheat allergy (WA). Although NCGS frequency is still unclear, epidemiological data have been generated that can help establishing the magnitude of the problem. Clinical studies further defined the identity of NCGS and its implications in human disease. An overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria. Several studies suggested a relationship between NCGS and neuropsychiatric disorders, particularly autism and schizophrenia. The first case reports of NCGS in children have been described. Lack of biomarkers is still a major limitation of clinical studies, making it difficult to differentiate NCGS from other gluten related disorders. Recent studies raised the possibility that, beside gluten, wheat amylase-trypsin inhibitors and low-fermentable, poorly-absorbed, short-chain carbohydrates can contribute to symptoms (at least those related to IBS) experienced by NCGS patients. In this paper we report the major advances and current trends on NCGS.

Indexed as

Diet, Gluten-FreeAutistic DisorderCeliac DiseaseGlutensHumansIntestinal DiseasesIntestinal MucosaIrritable Bowel SyndromeRandomized Controlled Trials as TopicSchizophreniaTerminology as TopicGlutens

Identifiers

PMID24077239
PMCPMC3820047
OpenAlexW2106418038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.