ArticleNature nanotechnology2013
Programmable chemical controllers made from DNA.
Article in Nature nanotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed.
- DNA framework-based molecular transformer for logic-driven precision diagnostics.Science advances · 2026Article
- Conformation-programmed DNA computing.Science advances · 2026Article
- On Degradation-Induced Leak in Heterochiral DNA Strand Displacement Cascades.ACS synthetic biology · 2026Article
- A recursive enzymatic competition network capable of multitask molecular information processing.Nature chemistry · 2026Article
- Maximum likelihood estimation of log-affine models using detailed-balanced reaction networks.Journal of mathematical biology · 2025Article
- Supervised learning in DNA neural networks.Nature · 2025Article
- Programmable DNA-Based Molecular Neural Network Biocomputing Circuits for Solving Partial Differential Equations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Information propagation through enzyme-free catalytic templating of DNA dimerization with weak product inhibition.Nature chemistry · 2025Article
- A Localized Scalable DNA Logic Circuit System Based on the DNA Origami Surface.International journal of molecular sciences · 2025Article
- Chemical Logic Gates on Active Colloids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A DNA circuit that records molecular events.Science advances · 2024Article
- Real-time signal processing via chemical reactions for a microfluidic molecular communication system.Nature communications · 2023Article
- Chemical reaction motifs driving non-equilibrium behaviours in phase separating materials.Journal of the Royal Society, Interface · 2023Article
- A geometric framework for reaction enumeration in computational nucleic acid devices.Journal of the Royal Society, Interface · 2023Article
- Generation of DNA oligomers with similar chemical kinetics via in-silico optimization.Communications chemistry · 2023Article
- Parallel molecular computation on digital data stored in DNA.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Accelerating DNA computing via freeze-thaw cycling.Science advances · 2023Article
- Leveraging Steric Moieties for Kinetic Control of DNA Strand Displacement Reactions.Journal of the American Chemical Society · 2023Article
- Pneumatic computers for embedded control of microfluidics.Science advances · 2023Article
- A reaction network scheme for hidden Markov model parameter learning.Journal of the Royal Society, Interface · 2023Article
51 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Biological organisms use complex molecular networks to navigate their environment and regulate their internal state. The development of synthetic systems with similar capabilities could lead to applications such as smart therapeutics or fabrication methods based on self-organization. To achieve this, molecular control circuits need to be engineered to perform integrated sensing, computation and actuation. Here we report a DNA-based technology for implementing the computational core of such controllers. We use the formalism of chemical reaction networks as a 'programming language' and our DNA architecture can, in principle, implement any behaviour that can be mathematically expressed as such. Unlike logic circuits, our formulation naturally allows complex signal processing of intrinsically analogue biological and chemical inputs. Controller components can be derived from biologically synthesized (plasmid) DNA, which reduces errors associated with chemically synthesized DNA. We implement several building-block reaction types and then combine them into a network that realizes, at the molecular level, an algorithm used in distributed control systems for achieving consensus between multiple agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.