ArticleNature nanotechnology2013
Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets.
Article in Nature nanotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers.
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Who cites it
168 citing papers in PubMed, 531 citations in OpenAlex.
- Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes.Lab on a chip · 2014Trial
- A Multifunctional Double-Array Petals Flower-Shaped Microfluidic Chip Combining Affinity and Physical Properties in Isolation of CTCs.Micromachines · 2026Article
- Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review).Oncology reports · 2026Review
- Isolation of Exosomes from MDA-MB-231 Cells Using a Paddle Screw System and Detection of TNBC-Associated Exosomal miRNAs.Micromachines · 2026Article
- Circulating Tumor Cells: Emerging Frontiers in Cancer Technology.Expert reviews in molecular medicine · 2026Review
- Isolation and typing techniques for circulating tumor cells.Biomarker research · 2026Review
- Liquid biopsy of circulating tumor cells: From isolation, enrichment, and genome sequencing to clinical applications.Histology and histopathology · 2025Review
- Article
- Overcoming Challenges in Colloidal and Chemical Stability of Graphene Oxide with Exploration of Dispersing Solvent.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- The Application of Microfluidic Chips in Primary Urological Cancer: Recent Advances and Future Perspectives.Smart medicine · 2025Review
- LbL-Antibody Embedded Gold Mesh: An Effective Method for Early Detection of Circulating Tumor Cells.International journal of nanomedicine · 2025Article
- Characterization of circulating tumor cells in patients with metastatic bladder cancer utilizing functionalized microfluidics.Neoplasia (New York, N.Y.) · 2024Article
- Biomedical applications of graphene-based nanomaterials: recent progress, challenges, and prospects in highly sensitive biosensors.Discover nano · 2024Review
- Functionalized tetrahedral DNA frameworks for the capture of circulating tumor cells.Nature protocols · 2024Review
- Dissemination of Circulating Tumor Cells in Breast and Prostate Cancer: Implications for Early Detection.Endocrinology · 2024Review
- Graphene Oxide Nanoparticles and Organoids: A Prospective Advanced Model for Pancreatic Cancer Research.International journal of molecular sciences · 2024Review
- Targeting circulating tumor cells to prevent metastases.Human cell · 2024Review
- Microfluidics engineering towards personalized oncology-a review.In vitro models · 2023Review
- Advances of nanotechnology applied to cancer stem cells.World journal of stem cells · 2023Review
- A nucleolin-activated polyvalent aptamer nanoprobe for the detection of cancer cells.Analytical and bioanalytical chemistry · 2023Article
108 more citing papers are in PubMed but not listed here.
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12 authors at 2 institutions in 1 country.
Funding
Abstract
The spread of cancer throughout the body is driven by circulating tumour cells (CTCs). These cells detach from the primary tumour and move from the bloodstream to a new site of subsequent tumour growth. They also carry information about the primary tumour and have the potential to be valuable biomarkers for disease diagnosis and progression, and for the molecular characterization of certain biological properties of the tumour. However, the limited sensitivity and specificity of current methods for measuring and studying these cells in patient blood samples prevents the realization of their full clinical potential. The use of microfluidic devices is a promising method for isolating CTCs. However, the devices are reliant on three-dimensional structures, which limits further characterization and expansion of cells on the chip. Here we demonstrate an effective approach to isolating CTCs from blood samples of pancreatic, breast and lung cancer patients, by using functionalized graphene oxide nanosheets on a patterned gold surface. CTCs were captured with high sensitivity at a low concentration of target cells (73 ± 32.4% at 3-5 cells per ml blood).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.