ArticlePhysics in medicine and biology2013
Contrast-enhanced imaging of SPIO-labeled platelets using magnetomotive ultrasound.
Article in Physics in medicine and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- A finite element analysis model for magnetomotive ultrasound elastometry magnet design with experimental validation.Biomedical physics & engineering express · 2025Article
- Imaging-guided precision hyperthermia with magnetic nanoparticles.Nature reviews bioengineering · 2025Article
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- Elastometry of clot phantoms via magnetomotive ultrasound-based resonant acoustic spectroscopy.Physics in medicine and biology · 2022Article
- Modelling of magnetic microbubbles to evaluate contrast enhanced magnetomotive ultrasound in lymph nodes - a pre-clinical study.The British journal of radiology · 2022Article
- Single Magnetic Particle Motion in Magnetomotive Ultrasound: An Analytical Model and Experimental Validation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Inversion of displacement fields to quantify the magnetic particle distribution in homogeneous elastic media from magnetomotive ultrasound.Physics in medicine and biology · 2019Article
- Blind Source Separation-Based Motion Detector for Imaging Super-Paramagnetic Iron Oxide (SPIO) Particles in Magnetomotive Ultrasound Imaging.IEEE transactions on medical imaging · 2018Article
- Effect of Model Thrombus Volume and Elastic Modulus on Magnetomotive Ultrasound Signal Under Pulsatile Flow.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018Article
- Combined Magnetomotive ultrasound, PET/CT, and MR imaging ofScientific reports · 2017Article
- Blind Source Separation - Based Motion Detector for Sub-Micrometer, Periodic Displacement in Ultrasonic Imaging.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The ability to image platelets in vivo can provide insight into blood clotting processes and coagulopathies, and aid in identifying sites of vascular endothelial damage related to trauma or cardiovascular disease. Toward this end, we have developed a magnetomotive ultrasound (MMUS) system that provides contrast-enhanced imaging of superparamagnetic iron oxide (SPIO) labeled platelets via magnetically-induced vibration. Platelets are a promising platform for functional imaging contrast because they readily take up SPIOs and are easily harvested from blood. Here we report a novel MMUS system that accommodates an arbitrarily thick sample while maintaining portability. We employed a frequency- and phase-locked motion detection algorithm based on bandpass filtering of the differential RF phase, which allows for the detection of sub-resolution vibration amplitudes on the order of several nanometers. We then demonstrated MMUS in homogenous tissue phantoms at SPIO concentrations as low as 0.09 mg ml(-1) Fe (p < 0.0001, n = 6, t-test). Finally, we showed that our system is capable of three-dimensional imaging of a 185 µL simulated clot containing SPIO-platelets. This highlights the potential utility for non-invasive imaging of platelet-rich clots, which would constitute a fundamental advance in technology for the study of hemostasis and detection of clinically relevant thrombi.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.