Evidence map›Paper›PMID 24076978›Full record

ArticleThe Plant cell2013

Establishing a framework for the Ad/abaxial regulatory network of Arabidopsis: ascertaining targets of class III homeodomain leucine zipper and KANADI regulation.

Brenda J Reinhart, Tie Liu, Nicole R Newell, Enrico Magnani, Tengbo Huang, Randall Kerstetter, Scott Michaels, M Kathryn Barton

Open access · greenAbstract read
In one paragraph

Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

  1. Pooled it
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  14. Plants (Basel, Switzerland) · 2023
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  16. The Non-JAZ TIFY Protein TIFY8 ofInternational journal of molecular sciences · 2023
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  18. Genome-Wide Identification of the Highly ConservedInternational journal of molecular sciences · 2022
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  20. MicroRNA-resistant alleles ofScience advances · 2022
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Brenda J ReinhartDepartment of Plant Biology, Carnegie Institution for Science, Stanford, California 94305.
Tie Liu
Nicole R Newell
Enrico Magnani
Tengbo Huang
Randall Kerstetter
Scott Michaels
M Kathryn Barton
Carnegie Institution for Science · USRutgers, The State University of New Jersey · USIndiana University Bloomington · US

Funding

Posttranscriptional control of meristem developmentR01GM069293 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI BARTON, KATHRYN M · 2003 to 2006
$1.1M
NIGMS NIH HHS R01 GM069293
6 · The paper itself

Abstract

The broadly conserved Class III homeodomain leucine zipper (HD-ZIPIII) and KANADI transcription factors have opposing and transformational effects on polarity and growth in all tissues and stages of the plant's life. To obtain a comprehensive understanding of how these factors work, we have identified transcripts that change in response to induced HD-ZIPIII or KANADI function. Additional criteria used to identify high-confidence targets among this set were presence of an adjacent HD-ZIPIII binding site, expression enriched within a subdomain of the shoot apical meristem, mutant phenotype showing defect in polar leaf and/or meristem development, physical interaction between target gene product and HD-ZIPIII protein, opposite regulation by HD-ZIPIII and KANADI, and evolutionary conservation of the regulator-target relationship. We find that HD-ZIPIII and KANADI regulate tissue-specific transcription factors involved in subsidiary developmental decisions, nearly all major hormone pathways, and new actors (such as indeterminate domain4) in the ad/abaxial regulatory network. Multiple feedback loops regulating HD-ZIPIII and KANADI are identified, as are mechanisms through which HD-ZIPIII and KANADI oppose each other. This work lays the foundation needed to understand the components, structure, and workings of the ad/abaxial regulatory network directing basic plant growth and development.

Indexed as

Gene Expression Regulation, PlantArabidopsisArabidopsis ProteinsBinding SitesBody PatterningDown-RegulationGene ExpressionGene Expression ProfilingGene Regulatory NetworksHomeodomain ProteinsMeristemModels, BiologicalMutationOligonucleotide Array Sequence AnalysisPhenotypePhylogenyArabidopsis ProteinsHD-Zip protein, ArabidopsisHomeodomain ProteinsIFL1 protein, ArabidopsisKANADI protein, ArabidopsisTranscription Factors

Identifiers

PMID24076978
PMCPMC3809529
OpenAlexW2130705431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.