ArticleThe Plant cell2013
An-1 encodes a basic helix-loop-helix protein that regulates awn development, grain size, and grain number in rice.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 2 of them syntheses that pooled it.
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Who cites it
131 citing papers in PubMed, 2 syntheses or guidelines pooled it, 271 citations in OpenAlex.
- Integrative systems biology analysis of barley transcriptome ─ hormonal signaling against biotic stress.PloS one · 2023Pooled it
- Meta-QTLs, ortho-meta-QTLs and candidate genes for grain yield and associated traits in wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Pooled it
- Negative Regulators of Rice Agronomic Traits: Functional Insights and Applications in Genome Editing-Based Breeding.Plant biotechnology journal · 2026Review
- Insights into the genetic basis of natural selection and domestication from Sorghum.Scientific reports · 2026Article
- To awn or not to awn: Revisiting the evolution of awnedness during rice domestication and improvement.Plant communications · 2026Review
- TaAGL6-B1 identified as a candidate gene for the dominant awn-inhibitor locus B2 in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A pendant awn phenotype linked to the EMBRYONIC FLOWER 1 LIKE (EMF1L) gene in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- A Forward Genetics Strategy for High-Throughput Gene Identification via Precise Image-Based Phenotyping of an Indexed EMS Mutant Library.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An AP2/ERF transcription factor controls generation of the twin-seedling rice.Journal of advanced research · 2025Article
- Turbo-charging crop improvement: harnessing multiplex editing for polygenic trait engineering and beyond.The Plant journal : for cell and molecular biology · 2025Review
- McATL43 encoding a RING-H2 finger E3 ubiquitin ligase is responsible for Shark teeth (St) fruit wart in bitter gourd (Momordica charantia L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Article
- A pangenome reference of wild and cultivated rice.Nature · 2025Article
- SHORT AND CROOKED AWN, encoding the epigenetic regulator EMF1, promotes barley awn development.Plant & cell physiology · 2025Article
- Harnessing neo-domestication of wild pigmented rice for enhanced nutrition and sustainable agriculture.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Rice grain size: current regulatory mechanisms and future perspectives.Journal of plant research · 2025Review
- Correlation of rice yield based on RILs population QTL analysis.BMC genomic data · 2025Article
- The natural variation allele OsGSW3.2 in Oryza rufipogon is involved in brassinosteroid signaling and influences grain size and weight.The Plant journal : for cell and molecular biology · 2025Article
- Transcriptomic analysis offers deep insights into the Increased Grain Length 1 (IGL1) regulation of grain length.BMC plant biology · 2025Article
- Revisiting development and physiology of wild rice relatives for crop improvement and climate resilience.Plant cell reports · 2025Review
71 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long awns are important for seed dispersal in wild rice (Oryza rufipogon), but are absent in cultivated rice (Oryza sativa). The genetic mechanism involved in loss-of-awn in cultivated rice remains unknown. We report here the molecular cloning of a major quantitative trait locus, An-1, which regulates long awn formation in O. rufipogon. An-1 encodes a basic helix-loop-helix protein, which regulates cell division. The nearly-isogenic line (NIL-An-1) carrying a wild allele An-1 in the genetic background of the awnless indica Guangluai4 produces long awns and longer grains, but significantly fewer grains per panicle compared with Guangluai4. Transgenic studies confirmed that An-1 positively regulates awn elongation, but negatively regulates grain number per panicle. Genetic variations in the An-1 locus were found to be associated with awn loss in cultivated rice. Population genetic analysis of wild and cultivated rice showed a significant reduction in nucleotide diversity of the An-1 locus in rice cultivars, suggesting that the An-1 locus was a major target for artificial selection. Thus, we propose that awn loss was favored and strongly selected by humans, as genetic variations at the An-1 locus that cause awn loss would increase grain numbers and subsequently improve grain yield in cultivated rice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.