Evidence map›Paper›PMID 2407656›Full record

ArticleInfection and immunity1990

Protein phosphorylation by protein kinase C in HEp-2 cells infected with enteropathogenic Escherichia coli.

T J Baldwin, S F Brooks, S Knutton, H A Manjarrez Hernandez, A Aitken, P H Williams

Erratum issuedAbstract read
In one paragraph

Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Diarrheagenic Escherichia coli.Clinical microbiology reviews · 1998
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  17. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.Proceedings of the National Academy of Sciences of the United States of America · 1995
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

6 authors.

T J BaldwinDepartment of Genetics, University of Leicester, United Kingdom.
S F Brooks
S Knutton
H A Manjarrez Hernandez
A Aitken
P H Williams

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection of HEp-2 monolayers with enteropathogenic Escherichia coli 2036-80 (O119) stimulated phosphorylation of several target cell proteins, the most prominent of which had apparent molecular weights of 21,000 and 29,000. Proteins of the same size were phosphorylated in response to known activators of the calcium-phospholipid-dependent protein kinase C. Screening of clinical isolates of various O serogroups revealed that all strains able to form the characteristic attaching and effacing lesion of enteropathogenic E. coli showed elevated phosphorylation of 21,000- and 29,000-dalton protein species.

Indexed as

Bacterial AdhesionEnzyme ActivationEscherichia coli InfectionsHumansLaryngeal NeoplasmsMolecular WeightPhosphoproteinsPhosphorylationProtein Kinase CProteinsTumor Cells, CulturedPhosphoproteinsProtein Kinase CProteins

Identifiers

PMID2407656
PMCPMC258530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.