ArticleInfection and immunity1990
Effective vaccination of mice against leprosy bacilli with subunits of Mycobacterium leprae.
Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Combination chemoprophylaxis and immunoprophylaxis in reducing the incidence of leprosy.Risk management and healthcare policy · 2016Review
- Advances and hurdles on the way toward a leprosy vaccine.Human vaccines · 2011Review
- Vaccination with the ML0276 antigen reduces local inflammation but not bacterial burden during experimental Mycobacterium leprae infection.Infection and immunity · 2009Article
- Effect of vaccination with refined components of the organism on infection of mice with Mycobacterium leprae.Infection and immunity · 2003Article
- Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4(+) T cells.Infection and immunity · 2000Article
- Serological distinction of integral plasma membrane proteins as a class of mycobacterial antigens and their relevance for human T cell activation.Clinical and experimental immunology · 1995Article
- Chemotherapy of lepromatous leprosy: recent developments and prospects for the future.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1994Review
- Vaccination with pure Mycobacterium leprae proteins inhibits M. leprae multiplication in mouse footpads.Infection and immunity · 1994Article
- Isolation of Brucella abortus ssb and uvrA genes from a genomic library by use of lymphocytes as probes.Infection and immunity · 1993Article
- Hansen's disease.The Western journal of medicine · 1993Review
- Host response to Mycobacterial cell wall subunit during experimental tuberculosis in mice.Folia microbiologica · 1993Article
- Cellular immune response to the cell walls of Mycobacterium leprae in leprosy patients and healthy subjects exposed to leprosy.Clinical and experimental immunology · 1992Article
- Antigens of Brucella abortus S19 immunodominant for bovine lymphocytes as identified by one- and two-dimensional cellular immunoblotting.Infection and immunity · 1992Article
- Vaccination of mice with a soluble protein fraction of Mycobacterium leprae provides consistent and long-term protection against M. leprae infection.Infection and immunity · 1992Article
- Protective efficacy of different cell-wall fractions of Mycobacterium tuberculosis.Folia microbiologica · 1992Article
- Review
- Identification of an immunostimulating protein from Mycobacterium leprae.Infection and immunity · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Model vaccines against leprosy bacilli have consisted of nonvirulent, live, attenuated Mycobacterium bovis BCG and irradiated, heat-killed, or autoclaved intact M. leprae. We report that immunization with various cell wall fractions of M. leprae, progressively depleted of lipids, carbohydrates, and soluble proteins, as well as a partially purified protein(s) derived from a pellet fraction of sonicated M. leprae, conferred significant protection against subsequent infection with live leprosy bacilli. Moreover, lymphocytes from regional lymph nodes and spleens of mice immunized with these M. leprae-derived subunits responded by proliferation when stimulated with M. leprae in vitro. Our results provide the first evidence that vaccination with M. leprae-derived fractions protects mice against leprosy bacilli.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.