ReviewNeuroscience and biobehavioral reviews2013
Cognitive unbinding: a neuroscientific paradigm of general anesthesia and related states of unconsciousness.
Review in Neuroscience and biobehavioral reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03290495 (Electroencephalographic Effects of Ketamine During Isoflurane Maintenance and Recovery), which is not on this map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electroencephalographic Effects of Ketamine During Isoflurane Maintenance and Recovery
Who cites it
45 citing papers in PubMed.
- Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial.BMC anesthesiology · 2025Trial
- Disruption of cortical integration during midazolam-induced light sedation.Human brain mapping · 2015Trial
- How sleeping minds decide: State-specific reconfigurations of lexical decision-making.PLoS computational biology · 2026Article
- Convergent Recruitment of Cerebellar Purkinje Cells by Mechanistically Diverse General Anesthetics.Journal of neurochemistry · 2025Article
- High-dose medetomidine increases functional connectivity in the fear-related regions after electrical stimulation.Scientific reports · 2025Article
- Overview and Clinical Applications of Artificial Intelligence and Machine Learning in Cardiac Anesthesiology.Journal of cardiothoracic and vascular anesthesia · 2024Review
- Brain state identification and neuromodulation to promote recovery of consciousness.Brain communications · 2024Review
- Touching the unconscious in the unconscious - hypnotic communication with unconscious patients.Frontiers in psychology · 2024Review
- The nature of consciousness in anaesthesia.BJA open · 2023Review
- Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat.BMC anesthesiology · 2023Article
- Theories of consciousness.Nature reviews. Neuroscience · 2022Review
- Consciousness, Cognition and the Neuronal Cytoskeleton - A New Paradigm Needed in Neuroscience.Frontiers in molecular neuroscience · 2022Article
- Article
- Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Foundations of Human Consciousness: Imaging the Twilight Zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Anesthesia-induced loss of consciousness disrupts auditory responses beyond primary cortex.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Sleep Disturbances After General Anesthesia: Current Perspectives.Frontiers in neurology · 2020Review
- Potential Neural Mediators of Mom Power Parenting Intervention Effects on Maternal Intersubjectivity and Stress Resilience.Frontiers in psychiatry · 2020Article
- The Biology of General Anesthesia from Paramecium to Primate.Current biology : CB · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
"Cognitive unbinding" refers to the impaired synthesis of specialized cognitive activities in the brain and has been proposed as a mechanistic paradigm of unconsciousness. This article draws on recent neuroscientific data to revisit the tenets and predictions of cognitive unbinding, using general anesthesia as a representative state of unconsciousness. Current evidence from neuroimaging and neurophysiology supports the proposition that cognitive unbinding is a parsimonious explanation for the direct mechanism (or "proximate cause") of anesthetic-induced unconsciousness across multiple drug classes. The relevance of cognitive unbinding to sleep, disorders of consciousness, and psychological processes is also explored. It is concluded that cognitive unbinding is a viable neuroscientific framework for unconscious processes across the fields of anesthesiology, sleep neurobiology, neurology and psychoanalysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.