ArticlePain2014
Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat.
Article in Pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Repetitive daily oxytocin treatment reduces weight gain but not acute neonatal procedural pain.Pediatric research · 2025Article
- Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway.Frontiers in systems neuroscience · 2022Review
- Pain sensing neurons promote tissue regeneration in adult mice.NPJ Regenerative medicine · 2021Article
- Tissue Regeneration: The Dark Side of Opioids.International journal of molecular sciences · 2021Review
- Identifying the Neurodevelopmental Differences of Opioid Withdrawal.Cellular and molecular neurobiology · 2021Article
- Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model.Pediatric research · 2021Article
- Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children.PLoS computational biology · 2021Article
- Endogenous opioid peptides in the descending pain modulatory circuit.Neuropharmacology · 2020Review
- The development of pain circuits and unique effects of neonatal injury.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- μ-Opioid receptors in primary sensory neurons are involved in supraspinal opioid analgesia.Brain research · 2020Article
- The Role of the Periaqueductal Gray Matter in Lower Urinary Tract Function.Molecular neurobiology · 2019Review
- Article
- Top-down control of pain.The Journal of physiology · 2017Article
- The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord.Scientific reports · 2017Article
- Lifetime Modulation of the Pain SystemFrontiers in immunology · 2017Review
- Neurobiological Mechanism of Acupuncture for Relieving Visceral Pain of Gastrointestinal Origin.Gastroenterology research and practice · 2017Review
- Neuron-immune mechanisms contribute to pain in early stages of arthritis.Journal of neuroinflammation · 2016Article
- Article
- Targeting p38 Mitogen-activated Protein Kinase to Reduce the Impact of Neonatal Microglial Priming on Incision-induced Hyperalgesia in the Adult Rat.Anesthesiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control of spinal excitability via the dorsal horn (DH). Here we report developmentally regulated changes in the opioidergic signalling within the PAG and DH, which further increase our understanding of pain processing during early life. Microinjection of the μ-opioid receptor (MOR) agonist DAMGO (30 ng) into the PAG of Sprague-Dawley rats increased spinal excitability and lowered mechanical threshold to noxious stimuli in postnatal day (P)21 rats, but had inhibitory effects in adults and lacked efficacy in P10 pups. A tonic opioidergic tone within the PAG was revealed in adult rats by intra-PAG microinjection of CTOP (120 ng, MOR antagonist), which lowered mechanical thresholds and increased spinal reflex excitability. Spinal administration of DAMGO inhibited spinal excitability in all ages, yet the magnitude of this was greater in younger animals than in adults. The expression of MOR and related peptides were also investigated using TaqMan real-time polymerase chain reaction and immunohistochemistry. We found that pro-opiomelanocortin peaked at P21 in the ventral PAG, and MOR increased significantly in the DH as the animals aged. Enkephalin mRNA transcripts preceded the increase in enkephalin immunoreactive fibres in the superficial dorsal horn from P21 onwards. These results illustrate that profound differences in the endogenous opioidergic signalling system occur throughout postnatal development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.