Evidence map›Paper›PMID 24076116›Full record

ArticleImmunology letters

Hematopoietic defects and iPSC disease modeling: lessons learned.

James M Kelley, George Q Daley

Abstract read
In one paragraph

Article in Immunology letters. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist.Cellular and molecular life sciences : CMLS · 2014
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

James M KelleyDepartment of Pathology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.
George Q Daley
Dana-Farber Cancer Institute · USHarvard University · US

Funding

Customized stem cells for clinical application in blood disordersR24DK092760 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2011 to 2018
$10.7M
Human Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood DiseasesU01HL100001 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, ORKIN, STUART H · 2009 to 2015
$8.9M
Modeling and correcting human SCID using patient-derived iPS cellsR01AI100887 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI MANIS, JOHN P · 2012 to 2020
$4.5M
Novel therapies for Fanconi anemiaRC4DK090913 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI D'ANDREA, ALAN D., DALEY, GEORGE Q · 2010 to 2010
$3.9M
Role of HIV Envelope Proteins In Viral Replication and HIV PathogenesisZ01AI000887 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI FAUCI, ANTHONY S. · 2001 to 2008
$1.6M
Howard Hughes Medical InstituteIntramural NIH HHS Z01 AI000887NHLBI NIH HHS U01 HL100001NHLBI NIH HHS U01-HL100001NIAID NIH HHS R01-AI00887NIAID NIH HHS R01 AI100887NIDDK NIH HHS R24 DK092760NIDDK NIH HHS R24-DK092760NIDDK NIH HHS RC4 DK090913NIDDK NIH HHS RC4-DK090913
6 · The paper itself

Abstract

Hematopoiesis is a paradigm for stem cell biology in that it centers on differentiation of a self-renewing pluripotent precursor into multiple committed cell types with specific functions. The use of induced pluripotent stem cells (iPSCs) as a disease modeling tool has revealed numerous insights into the underlying pathophysiology of hematological diseases - those disorders arising from defective hematopoiesis. Likewise, studying hematopoiesis and the defects that can arise offer clues to understanding general stem cell survival and differentiation.

Indexed as

HematopoiesisHematopoietic Stem Cell TransplantationAnimalsCell DifferentiationCellular ReprogrammingHematologic DiseasesHematopoietic Stem CellsHemoglobinsHumansInduced Pluripotent Stem CellsMutationHemoglobinsBone marrow failureDisease modelingInduced pluripotent stem cellsReprogramming

Identifiers

PMID24076116
PMCPMC3888024
OpenAlexW2025891705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.