ReviewBrain research bulletin2014
Does PKM(zeta) maintain memory?
Review in Brain research bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- PKMζ drives spatial memory reconsolidation but not maintenance.Frontiers in synaptic neuroscience · 2025Article
- Infusing zeta inhibitory peptide into the perirhinal cortex of rats abolishes long-term object recognition memory without affecting novel object location recognition.Frontiers in behavioral neuroscience · 2022Article
- PKMζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sustained CaMKII Delta Gene Expression Is Specifically Required for Long-Lasting Memories in Mice.Molecular neurobiology · 2019Article
- Molecular Mechanisms of the Memory Trace.Trends in neurosciences · 2019Review
- Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model.Frontiers in molecular neuroscience · 2019Article
- Remembering to Forget: A Dual Role for Sleep Oscillations in Memory Consolidation and Forgetting.Frontiers in cellular neuroscience · 2019Article
- In memoriam: John Lisman - commentaries on CaMKII as a memory molecule.Molecular brain · 2018Article
- A continuous model of physiological prion aggregation suggests a role for Orb2 in gating long-term synaptic information.Royal Society open science · 2018Article
- Developmental transitions in amygdala PKC isoforms and AMPA receptor expression associated with threat memory in infant rats.Scientific reports · 2018Article
- The Synaptic Theory of Memory: A Historical Survey and Reconciliation of Recent Opposition.Frontiers in systems neuroscience · 2018Article
- MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?Current neuropharmacology · 2017Review
- Memory Retrieval Has a Dynamic Influence on the Maintenance Mechanisms That Are Sensitive to ζ-Inhibitory Peptide (ZIP).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain.Journal of neurochemistry · 2016Article
- ZIP It: Neural Silencing Is an Additional Effect of the PKM-Zeta Inhibitor Zeta-Inhibitory Peptide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Overexpression of Protein Kinase Mζ in the Hippocampus Enhances Long-Term Potentiation and Long-Term Contextual But Not Cued Fear Memory in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Computational principles of memory.Nature neuroscience · 2016Review
- Increased N-Ethylmaleimide-Sensitive Factor Expression in Amygdala and Perirhinal Cortex during Habituation of Taste Neophobia.Neural plasticity · 2016Article
- The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.Nature communications · 2015Article
- Protein Kinase C (PKC)ζ Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation.Molecular pharmacology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory. PKMζ, an autonomously active isoform of PKC, is hypothesized to sustain those changes that occurred during memory formation in order to preserve the memory engram over time. Initial studies investigating the role of PKMζ were largely successful in demonstrating a role for the kinase in memory maintenance; disrupting PKMζ activity with ζ-inhibitory peptide (ZIP) was successful in disrupting a variety of established associations in a number of key brain regions. More recent work, however, has questioned both the role of PKMζ in memory maintenance and the effectiveness of ZIP as a specific inhibitor of PKMζ activity. Here, we outline the research both for and against the idea that PKMζ is a memory maintenance mechanism and discuss how these two lines of research can be reconciled. We conclude by proposing a number of studies that would help to clarify the role of PKMζ in memory and define other mechanisms the brain may use to maintain memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.