ReviewBiochimica et biophysica acta2013
O-GlcNAcylation at promoters, nutrient sensors, and transcriptional regulation.
Review in Biochimica et biophysica acta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells.Frontiers in immunology · 2024Article
- Review
- Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.International journal of biological macromolecules · 2021Article
- Article
- Targeted covalent inhibition of O-GlcNAc transferase in cells.Chemical communications (Cambridge, England) · 2019Article
- 'Molecules (Basel, Switzerland) · 2018Review
- Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.Nature structural & molecular biology · 2017Article
- O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β.The Journal of biological chemistry · 2016Article
- The pol II CTD: new twists in the tail.Nature structural & molecular biology · 2016Review
- O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity.Oncotarget · 2016Article
- Human RNA Polymerase II Promoter Recruitment in Vitro Is Regulated by O-Linked N-Acetylglucosaminyltransferase (OGT).The Journal of biological chemistry · 2016Article
- Distributive O-GlcNAcylation on the Highly Repetitive C-Terminal Domain of RNA Polymerase II.Biochemistry · 2016Article
- Review
- Establishment of a sticky, large, oval-shaped thrombocyte cell line from tree frog as an ancestor of mammalian megakaryocytes.SpringerPlus · 2015Article
- Multiple tissue-specific roles for the O-GlcNAc post-translational modification in the induction of and complications arising from type II diabetes.The Journal of biological chemistry · 2014Review
- Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Altering O-linked β-N-acetylglucosamine cycling disrupts mitochondrial function.The Journal of biological chemistry · 2014Article
- Three Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism.Frontiers in endocrinology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Post-translational modifications play important roles in transcriptional regulation. Among the less understood PTMs is O-GlcNAcylation. Nevertheless, O-GlcNAcylation in the nucleus is found on hundreds of transcription factors and coactivators and is often found in a mutually exclusive ying-yang relationship with phosphorylation. O-GlcNAcylation also links cellular metabolism directly to the proteome, serving as a conduit of metabolic information to the nucleus. This review serves as a brief introduction to O-GlcNAcylation, emphasizing its important thematic roles in transcriptional regulation, and highlights several recent and important additions to the literature that illustrate the connections between O-GlcNAc and transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.