ArticleNeurobiology of learning and memory2013
Nuclear gating of a Drosophila dCREB2 activator is involved in memory formation.
Article in Neurobiology of learning and memory, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Transcription Factor Evolution Associated with Social Transitions in Blattodea.Journal of molecular evolution · 2026Article
- Reassessing the involvement of the CREB pathway in the circadian clock of Drosophila melanogaster.Npj biological timing and sleep · 2024Article
- The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila.Cell death & disease · 2022Article
- Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.Molecules and cells · 2019Article
- Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit.eLife · 2018Article
- A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.eLife · 2018Article
- Article
- Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Spatio-temporal in vivo recording of dCREB2 dynamics in Drosophila long-term memory processing.Neurobiology of learning and memory · 2015Article
- Time of day influences memory formation and dCREB2 proteins in Drosophila.Frontiers in systems neuroscience · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The transcription factor CREB is an important regulator of many adaptive processes in neurons, including sleep, cellular homeostasis, and memory formation. The Drosophila dCREB2 family includes multiple protein isoforms generated from a single gene. Overexpression of an activator or blocker isoform has been shown to enhance or block memory formation, but the molecular mechanisms underlying these phenomena remain unclear. In the present study, we generate isoform-specific antibodies and new transgenic flies to track and manipulate the activity of different dCREB2 isoforms during memory formation. We find that nuclear accumulation of a dCREB2 activator-related species, p35+, is dynamically regulated during memory formation. Furthermore, various dCREB2 genetic manipulations that enhance or block memory formation correspondingly increase or decrease p35+ levels in the nucleus. Finally, we show that overexpression of S6K can enhance memory formation and increase p35+ nuclear abundance. Taken together, these results suggest that regulation of dCREB2 localization may be a key molecular convergence point in the coordinated host of events that lead to memory formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.